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1. (WO2010124116) AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Pub. No.:    WO/2010/124116    International Application No.:    PCT/US2010/032092
Publication Date: Fri Oct 29 01:59:59 CEST 2010 International Filing Date: Fri Apr 23 01:59:59 CEST 2010
IPC: C07D 401/06
C07D 417/06
C07D 205/04
C07D 401/12
C07D 409/06
A61K 31/496
A61P 25/00
A61P 29/00
Applicants: JANSSEN PHARMACEUTICA NV
BIAN, Haiyan
CHEVALIER, Kristen, M.
CONNOLLY, Peter, J.
FLORES, Christopher, M.
LIN, Shu-chen
LIU, Li
MABUS, John
MACIELAG, Mark, J.
MCDONNELL, Mark, E.
PITIS, Philip, M.
ZHANG, Yue-mei
ZHANG, Sui-po
ZHU, Bin
CLEMENTE, Jose
Inventors: BIAN, Haiyan
CHEVALIER, Kristen, M.
CONNOLLY, Peter, J.
FLORES, Christopher, M.
LIN, Shu-chen
LIU, Li
MABUS, John
MACIELAG, Mark, J.
MCDONNELL, Mark, E.
PITIS, Philip, M.
ZHANG, Yue-mei
ZHANG, Sui-po
ZHU, Bin
CLEMENTE, Jose
Title: AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
Abstract:
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: Formula (I) wherein Y, Z, R1, and s are defined herein.