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1. (WO2010124047) BISARYL ALKYNYLAMIDES AS NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/124047    International Application No.:    PCT/US2010/031982
Publication Date: 28.10.2010 International Filing Date: 22.04.2010
IPC:
C07D 209/44 (2006.01), C07D 401/10 (2006.01), C07D 407/14 (2006.01), C07D 409/14 (2006.01), C07D 413/04 (2006.01), C07D 417/14 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01), C07D 495/04 (2006.01), C07D 498/04 (2006.01), C07D 513/04 (2006.01), A61K 31/4035 (2006.01), A61P 25/16 (2006.01), A61P 25/18 (2006.01), A61P 25/22 (2006.01)
Applicants: WYETH LLC [US/US]; Five Giralda Farms Madison, NJ 07940 (US) (For All Designated States Except US).
LI, David, Zenan [US/US]; (US) (For US Only).
O'NEIL, Steven, Victor [US/US]; (US) (For US Only).
SPRINGER, Dane, Mark [US/US]; (US) (For US Only).
ZEGARELLI, Benjamin, Miller [US/US]; (US) (For US Only)
Inventors: LI, David, Zenan; (US).
O'NEIL, Steven, Victor; (US).
SPRINGER, Dane, Mark; (US).
ZEGARELLI, Benjamin, Miller; (US)
Agent: HERMAN, Michael; Pfizer Patent Law Department Five Giralda Farms Madison, NJ 07940 (US)
Priority Data:
61/171,878 23.04.2009 US
Title (EN) BISARYL ALKYNYLAMIDES AS NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5)
(FR) BISARYL ALCYNYLAMIDES EN TANT QUE MODULATEURS ALLOSTÉRIQUES NÉGATIFS DU RÉCEPTEUR MÉTABOTROPIQUE DU GLUTAMATE 5 (MGLUR5)
Abstract: front page image
(EN)Disclosed are compounds of Formula (I): pharmaceutical compositions containing compounds of Formula I, and the use of compounds of Formula (I) to treat diseases and disorders including schizophrenia, paranoia, depression, manic-depressive illness and anxiety wherein W1-W5, X1-X4, Y, Z1-Z5, m, n, p, and R1-R6 in Formula (I) are defined in the specification.
(FR)L'invention porte sur des composés de Formule (I) : sur des compositions pharmaceutiques contenant les composés de formule (I) et sur l'utilisation de composés de Formule (I) pour traiter des maladies et des troubles comprenant la schizophrénie, la paranoïa, la dépression, la psychose maniaco-dépressive et l'anxiété. Dans la Formule (I), W1-W5, X1-X4, Y, Z1-Z5, m, n, p et R1-R6 sont tels que définis dans la description.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)