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1. (WO2010124046) 4-HYDROXYBUTYRIC ACID ANALOGS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/124046 International Application No.: PCT/US2010/031981
Publication Date: 28.10.2010 International Filing Date: 22.04.2010
IPC:
C07B 59/00 (2006.01) ,C07C 59/01 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59
Introduction of isotopes of elements into organic compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
59
Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
01
Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
Applicants: TUNG, Roger, D.[US/US]; US (UsOnly)
CONCERT PHARMACEUTICALS, INC.[US/US]; 99 Hayden Avenue Suite 500 Lexington, MA 02421, US (AllExceptUS)
Inventors: TUNG, Roger, D.; US
Agent: DAVIS, Steven, G.; McCarter & English, LLP 265 Franklin Street Boston, MA 02110, US
Priority Data:
61/214,38223.04.2009US
61/287,56117.12.2009US
Title (EN) 4-HYDROXYBUTYRIC ACID ANALOGS
(FR) ANALOGUES DE L'ACIDE 4-HYDROXYBUTYRIQUE
Abstract:
(EN) This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
(FR) La présente invention porte sur de nouveaux dérivés de l'acide 4-hydroxybutyrique et les promédicaments de ces dérivés, ainsi que sur des sels pharmaceutiquement acceptables de ces dérivés et promédicaments. La présente invention porte également sur des compositions pharmaceutiques comprenant un composé de l'invention, ainsi que sur l'utilisation de ces compositions dans des méthodes de traitement de la narcolepsie, de la fibromyalgie, d'autres troubles ou états pathologiques qui sont avantageusement traités par une amélioration du sommeil nocturne ou par administration d'oxybate de sodium.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)