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1. (WO2010124004) NANOCARRIER THERAPY FOR TREATING INVASIVE TUMORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/124004    International Application No.:    PCT/US2010/031914
Publication Date: 28.10.2010 International Filing Date: 21.04.2010
IPC:
A61K 9/133 (2006.01), A61K 9/127 (2006.01), A61P 35/00 (2006.01)
Applicants: EMORY UNIVERSITY [US/US]; Office Of Technology Transfer 1599 Clifton Road, 4th Floor Atlanta, GA 30322 (US) (For All Designated States Except US).
GEORGIA INSTITUTE OF TECHNOLOGY [US/US]; 505 10th Street, N.W. Atlanta, GA 30332-0415 (US) (For All Designated States Except US).
MUNSON, Jennifer, M. [US/US]; (US) (For US Only).
BELLAMKONDA, Ravi, V. [US/US]; (US) (For US Only).
ARBISER, Jack, L. [US/US]; (US) (For US Only)
Inventors: MUNSON, Jennifer, M.; (US).
BELLAMKONDA, Ravi, V.; (US).
ARBISER, Jack, L.; (US)
Agent: BRADIN, David; Intellectual Property/technology Law P.O. Box 14329 Research Triangle Park, NC 27709 (US)
Priority Data:
61/171,745 22.04.2009 US
Title (EN) NANOCARRIER THERAPY FOR TREATING INVASIVE TUMORS
(FR) THÉRAPIE PAR NANOSUPPORT POUR TRAITER DES TUMEURS INVASIVES
Abstract: front page image
(EN)Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the invasiveness of the tumors, and inhibits tumor metastasis. The liposomes include cholesterol and chemically pure phospholipids that are essentially neutral and contain saturated fatty acids of between 16 and 18 carbon atoms, such as distearoylphosphatidyl choline, and can also include one or more pegylated phospholipids, such as DSPE-PEG.
(FR)Selon l'invention, des liposomes d'une taille inférieure à 200 nanomètres ciblent des tumeurs et de préférence distribuent du bleu d'imipramine aux tumeurs, comprenant des tumeurs cérébrales telles que des gliomes. Le bleu d'imipramine décroît l'invasivité des tumeurs, et inhibe les métastases de tumeur. Les liposomes comprennent du cholestérol et des phospholipides chimiquement purs qui sont essentiellement neutres et contiennent des acides gras saturés d'entre 16 et 18 atomes de carbone, tels que la distéaroylphosphatidyl choline, et peuvent également comprendre un ou plusieurs phospholipides pégylés, tels que le DSPE-PEG.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)