WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2010124000) MODIFIED CIPA GENE FROM CLOSTRIDIUM THERMOCELLUM FOR ENHANCED GENETIC STABILITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/124000    International Application No.:    PCT/US2010/031907
Publication Date: 28.10.2010 International Filing Date: 21.04.2010
IPC:
C12N 15/31 (2006.01), C12N 15/74 (2006.01), C12R 1/145 (2006.01)
Applicants: THE TRUSTEES OF DARTMOUTH COLLEGE [US/US]; 11 Rope Ferry Road Hanover, NH 03755 (US) (For All Designated States Except US).
CURRIE, Devin, Hedley [US/US]; (US) (For US Only).
MCBRIDE, John [US/US]; (US) (For US Only).
GUSS, Adam [US/US]; (US) (For US Only)
Inventors: CURRIE, Devin, Hedley; (US).
MCBRIDE, John; (US).
GUSS, Adam; (US)
Agent: CHEN, Xiaoyue; Lathrop & Gage LLP 4845 Pearl East Circle, Suite 201 Boulder, CO 80301 (US)
Priority Data:
61/171,197 21.04.2009 US
Title (EN) MODIFIED CIPA GENE FROM CLOSTRIDIUM THERMOCELLUM FOR ENHANCED GENETIC STABILITY
(FR) GÈNE CIPA MODIFIÉ DE CLOSTRIDIUM THERMOCELLUM POSSÉDANT UNE MEILLEURE STABILITÉ GÉNÉTIQUE
Abstract: front page image
(EN)Bacteria consume a variety of biomass-derived substrates and produce ethanol. The scaffoldin gene cipA from Clostridium thermocellum is modified to generate a mutated gene with enhanced genetic stability. This mutated cipA gene can be introduced into a heterologous host, such as Thermoanaerobacterium saccharolyticum. Other cellulosome components may be introduced into the host to build a full-sized cellulosome in T. saccharolyticum. Manipulation of the scaffoldin genes provides a new approach for enhancing ethanol production by biomass-fermenting microorganisms.
(FR)L'invention concerne la modification du gène cipA d'armature de Clostridium thermocellum pour générer un gène muté ayant une meilleure stabilité génétique. Ce gène cipA muté peut être introduit dans un hôte hétérologue, comme Thermoanaerobacterium saccharolyticum. D'autres composants de cellulosome peuvent être introduits dans l'hôte pour construire un cellulosome pleine longueur dans T. saccharolyticum. Certaines bactéries consommant divers substrats dérivés de la biomasse et produisant de l'éthanol, la manipulation des gènes d'armature est une nouvelle approche pour améliorer leur production d'éthanol par fermentation de la biomasse.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)