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1. (WO2010123997) CARBACEPHEM BETA-LACTAM ANTIBIOTICS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/123997 International Application No.: PCT/US2010/031904
Publication Date: 28.10.2010 International Filing Date: 21.04.2010
IPC:
C07D 463/22 (2006.01) ,A61K 31/437 (2006.01) ,A61P 31/04 (2006.01)
Applicants: MOSER, Heinz, E.[CH/US]; US (UsOnly)
WAGMAN, Allan, S.[US/US]; US (UsOnly)
ACHAOGEN, INC.[US/US]; 7000 Shoreline Court, 3rd Floor South San Francisco, California 94080, US (AllExceptUS)
Inventors: MOSER, Heinz, E.; US
WAGMAN, Allan, S.; US
Agent: WAGNER, Emily, W.; Seed Intellectual Property Law Group PLLC Suite 5400 701 Fifth Avenue Seattle, Washington 98104-7064, US
Priority Data:
61/171,66922.04.2009US
Title (EN) CARBACEPHEM BETA-LACTAM ANTIBIOTICS
(FR) ANTIBIOTIQUES BÊTA-LACTAMES CARBACÉPHÈMES
Abstract: front page image
(EN) Carbacephem β-lactam antibiotics having chemical structures (I) and (II) are disclosed: including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, R1, R2 and R6 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
(FR) L'invention porte sur des antibiotiques bêta-lactames carbacéphèmes représentés par les structures chimiques (I) et (II), comprenant leurs stéréoisomères, sels pharmaceutiquement acceptables, esters et promédicaments, où Ar2, R1, R2 et R6 sont tels que définis dans la description. Les composés sont utiles pour le traitement d'infections bactériennes, en particulier celles qui sont provoquées par Staphylococcus spp résistant à la méthycilline.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)