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1. WO2010123933 - COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING 1,3,4-OXADIAZOLE DERIVATIVES

Publication Number WO/2010/123933
Publication Date 28.10.2010
International Application No. PCT/US2010/031798
International Filing Date 20.04.2010
IPC
A61K 31/41 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
12Antidiarrhoeals
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 15/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
08for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
A61P 3/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
02Nutrients, e.g. vitamins, minerals
A61P 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
06Antiarrhythmics
Applicants
  • INSTITUTE FOR ONEWORLD HEALTH [US]/[US] (AllExceptUS)
  • RUSSELL, Michael Geoffrey Neil [GB]/[GB] (UsOnly)
  • DOYLE, Kevin James [GB]/[GB] (UsOnly)
Inventors
  • RUSSELL, Michael Geoffrey Neil
  • DOYLE, Kevin James
Agents
  • KONSKI, Antoinette F.
Priority Data
61/171,05620.04.2009US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING 1,3,4-OXADIAZOLE DERIVATIVES
(FR) COMPOSÉS, COMPOSITIONS ET MÉTHODES COMPRENANT DES DÉRIVÉS DU 1,3,4-OXADIAZOLE
Abstract
(EN) The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-IV) or compositions comprising these compounds, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
(FR) La présente invention porte sur des compositions et des méthodes pour traiter une maladie chez un animal, la maladie étant sensible à l'inhibition du polypeptide régulateur de la conductance transmembranaire de mucoviscidose (CFTR) fonctionnel par administration, à un mammifère qui en a besoin, d'une quantité efficace d'un composé défini dans la présente invention (comprenant les composés présentés dans les Tableaux 1-2 ou englobés par les formules I à IV) ou de compositions comprenant ces composés, permettant ainsi de traiter la maladie. La présente invention concerne en particulier une méthode de traitement de la diarrhée et de la maladie polykystique des reins.
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