WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
PATENTSCOPE will be unavailable a few hours for maintenance reason on Saturday 18.08.2018 at 9:00 AM CEST
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2010123874) ANTIBODIES SPECIFIC TO CADHERIN-17
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/123874 International Application No.: PCT/US2010/031719
Publication Date: 28.10.2010 International Filing Date: 20.04.2010
IPC:
C07K 16/28 (2006.01) ,G01N 33/574 (2006.01)
Applicants: ROHLFF, Christian[DE/GB]; GB (UsOnly)
TERRETT, Jonathan, Alexander[GB/US]; US (UsOnly)
OXFORD BIOTHERAPEUTICS LTD.[GB/GB]; 94a Milton Park Abingdon Oxon OX14 4RY, GB (AllExceptUS)
Inventors: ROHLFF, Christian; GB
TERRETT, Jonathan, Alexander; US
Agent: SILVA, Robin, M.; Morgan Lewis & Bockius LLP One Market, Spear Street Tower San Francisco, CA 94105, US
Priority Data:
61/170,98020.04.2009US
Title (EN) ANTIBODIES SPECIFIC TO CADHERIN-17
(FR) ANTICORPS SPÉCIFIQUES À LA CADHÉRINE-17
Abstract: front page image
(EN) The present disclosure provides antibodies, including isolated monoclonal antibodies, which specifically bind to Cadherin-17 with high affinity. Nucleic acid molecules encoding Cadherin-17 antibodies, expression vectors, host cells and methods for expressing the Cadherin-17 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the Cadherin-17 antibodies are also provided. Methods for detecting Cadherin-17, as well as methods for treating various cancers, including colorectal cancer, are disclosed.
(FR) La présente invention concerne des anticorps, y compris des anticorps monoclonaux isolés, qui se lient spécifiquement à la cadhérine-17 avec une affinité élevée. L'invention porte en outre sur des molécules d'acide nucléique codant pour les anticorps de la cadhérine-17, des vecteurs d'expression, des cellules hôtes et des méthodes d'expression des anticorps de la cadhérine-17. La présente invention concerne également des molécules bispécifiques et des compositions pharmaceutiques comprenant lesdits anticorps de cadhérine-17. L'invention concerne par ailleurs la détection de la cadhérine-17, ainsi que des méthodes de traitement de divers cancers, y compris le cancer colorectal.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)