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1. (WO2010123822) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/123822 International Application No.: PCT/US2010/031608
Publication Date: 28.10.2010 International Filing Date: 19.04.2010
IPC:
A01N 43/58 (2006.01) ,A61K 31/50 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
48
having rings with two nitrogen atoms as the only ring hetero atoms
58
1,2-Diazines; Hydrogenated 1,2-diazines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
Applicants:
PENROSE, Stephen David [GB/GB]; GB (UsOnly)
DOYLE, Kevin James [GB/GB]; GB (UsOnly)
INSTITUTE FOR ONEWORLD HEALTH [US/US]; 280 Utah Avenue, Suite 250 South San Francisco, California 94080, US (AllExceptUS)
Inventors:
PENROSE, Stephen David; GB
DOYLE, Kevin James; GB
Agent:
KONSKI, Antoinette F.; Foley & Lardner LLP 975 Page Mill Road Palo Alto, California 94304-1013, US
Priority Data:
61/171,04820.04.2009US
Title (EN) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES
(FR) COMPOSÉS, COMPOSITIONS ET MÉTHODES COMPRENANT DES DÉRIVÉS DE PYRIDAZINE SULFONAMIDE
Abstract:
(EN) The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-3 or encompassed by formula I-III) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
(FR) La présente invention porte sur des compositions et des méthodes destinés à traiter une maladie chez un animal, la maladie étant sensible à l'inhibition du polypeptide régulateur de la conductance transmembranaire de la mucoviscidose (CFTR) fonctionnel, par administration, à un animal qui en a besoin, d'une quantité efficace d'un composé défini dans la présente invention (comprenant les composés présentés dans les tableaux 1 à 3 ou définis par les formules I-III), ou de compositions contenant cette méthode, permettant ainsi de traiter la maladie. La présente invention porte en particulier sur une méthode pour le traitement de la diarrhée et de la maladie polykystique des reins.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)