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1. (WO2010123822) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES

Pub. No.:    WO/2010/123822    International Application No.:    PCT/US2010/031608
Publication Date: Fri Oct 29 01:59:59 CEST 2010 International Filing Date: Tue Apr 20 01:59:59 CEST 2010
IPC: A01N 43/58
A61K 31/50
Applicants: INSTITUTE FOR ONEWORLD HEALTH
PENROSE, Stephen David
DOYLE, Kevin James
Inventors: PENROSE, Stephen David
DOYLE, Kevin James
Title: COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES
Abstract:
The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-3 or encompassed by formula I-III) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.