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1. (WO2010123584) METHOD FOR TRANSDERMAL IONTOPHORETIC DELIVERY OF CHELATED AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/123584 International Application No.: PCT/US2010/001227
Publication Date: 28.10.2010 International Filing Date: 26.04.2010
IPC:
A61N 1/30 (2006.01) ,A61K 9/70 (2006.01) ,A61M 37/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
N
ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1
Electrotherapy; Circuits therefor
18
Applying electric currents by contact electrodes
20
continuous direct currents
30
Apparatus for iontophoresis or cataphoresis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
70
Web, sheet or filament bases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
37
Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Applicants: IMRAN, Mir[IN/US]; US (UsOnly)
HASHIM, Mir[US/US]; US (UsOnly)
PATEL, Sanjay[GB/US]; US (UsOnly)
BERENSON, Ronald, J.[US/US]; US (UsOnly)
INCUBE LABS, LLC[US/US]; 2051 Ringwood Avenue San Jose, CA 95131, US (AllExceptUS)
Inventors: IMRAN, Mir; US
HASHIM, Mir; US
PATEL, Sanjay; US
BERENSON, Ronald, J.; US
Agent: EKSTROM, Richard, C.; Ekstrom Law Group 650 Castro Street, Suite 120-248 Mountain View, CA 94041, US
Priority Data:
12/459,86207.07.2009US
61/214,64225.04.2009US
61/217,01123.05.2009US
Title (EN) METHOD FOR TRANSDERMAL IONTOPHORETIC DELIVERY OF CHELATED AGENTS
(FR) PROCÉDÉ D'ADMINISTRATION TRANSDERMIQUE IONTHOPHORÉTIQUE D'AGENTS CHÉLATÉS
Abstract:
(EN) Embodiments provide devices, systems and methods for the transdermal delivery of chelated compounds. One embodiment provides a method for the iontophoretic transdermal delivery of a chelated iron complex for the treatment of anemia. A first patch comprising an active electrode and a chelated iron complex is applied to the skin; a second patch containing an electrode is also applied. An electrical current is then delivered to the skin from the active electrode. The chelated complex is transported across the skin via electromotive force from the current, with the iron being substantially chromogenically unreactive with the skin during transport so that there is little or no tattooing of the skin due to the formation of insoluble oxidative products. The complex is then dissociated to release the iron where it may be bound by transferrin or ferritin for storage or metabolic use such as heme synthesis.
(FR) Des modes de réalisation de la présente invention comprennent des dispositifs, des systèmes et des procédés d'administration transdermique de composés chélatés. Un mode de réalisation comprend un procédé d'administration transdermique iontophorétique d'un complexe de fer chélaté pour le traitement de l'anémie. Un premier timbre comprenant une électrode active et un complexe de fer chélaté est appliqué sur la peau; un second timbre contenant une électrode est également appliqué. Un courant électrique est ensuite appliqué à la peau par l'électrode active. Le complexe chélaté est transporté au niveau de la peau par l'intermédiaire de la force électromotrice du courant, le fer ne réagissant sensiblement pas de manière chromogène avec la peau pendant le transport de sorte qu'il n'y qu'une faible ou aucune coloration de la peau due à la formation de produits d'oxydation insolubles. Le complexe est ensuite dissocié pour libérer le fer qui peut être lié à la transferrine ou la ferritine pour son stockage ou son usage métabolique tel que la synthèse hématique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)