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1. (WO2010123583) 1-ARYL OR 1-HETEROARYL-PYRIDO[B]INDOLES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/123583 International Application No.: PCT/US2010/001225
Publication Date: 28.10.2010 International Filing Date: 26.04.2010
IPC:
C07D 471/14 (2006.01) ,C07D 471/12 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/437 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
Applicants: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION[US/US]; 211 Conference Center 600 Henley Street Knoxville, TN 36996-4122, US (AllExceptUS)
Inventors: BUOLAMWINI, John, K.; US
PATIL, Shivaputra; US
ADDO, James, K.; US
SUTTLE, D., Parker; US
ZHANG, Ruiwen; US
ZHU, Zhengxiang; US
HORRICK, Sharma; US
Agent: ADLER, Benjamin, Aaron; Adler & Associates 8011 Candle Lane Houston, TX 77071, US
Priority Data:
61/214,58224.04.2009US
Title (EN) 1-ARYL OR 1-HETEROARYL-PYRIDO[B]INDOLES AND USES THEREOF
(FR) 1-ARYL OU 1-HÉTÉROARYL-PYRIDO[B]INDOLES ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) Provided herein are 1-aryl or 1-heteroarylsubstituted phenanthrene diketo acid compounds. These compounds comprise a β-carboline ring structure substituted at C1 with an aryl or heteroaryl moiety and individually substituted at C3-C8 and N9 with a C1-C4 alkyl, a C1-C4 alkoxy, a C1-C4 alkoxyphenyl, halogen, thiol, alkylthiol, sulfonyl, sulfomainde, amide, substituted amide, ester, nitrile, OH, amino, substituted amine, haloalkyl, haloalkoxy, acyl, or a hydrogen. Also provided are methods for inhibiting proliferation of a cancer cell or for treating a cell proliferative disease by contacting the cancer cell or tumor comprising the same with the compounds provided herein or by administering the compounds to a subject with a cell proliferative disease.
(FR) La présente invention concerne des composés dicéto-acides phénanthréniques à substitution 1-aryle ou 1-hétéroaryle. Ces composés comprennent une structure cyclique β-carboline substituée en C1 par une fraction aryle ou hétéroaryle et individuellement substituée en C3-C8 et N9 par un groupe alkyle en C1-C4 , alcoxy en C1-C4, alcoxyphényle en C1-C4, halogène, thiol, alkylthiol, sulfonyle, sulfonamide, amide, amide substitué amide, ester, nitrile, OH, amino, amine substituée, halogénoalkyle, halogénoalcoxy, acyle, ou un atome d'hydrogène. L'invention concerne également des procédés permettant d'inhiber la prolifération d'une cellule cancéreuse ou de traiter une maladie caractérisée par une prolifération cellulaire par mise en contact de la cellule cancéreuse ou de la tumeur la comprenant avec les composés proposés ou par administration des composés à un patent atteint d'une maladie proliférative.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)