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1. (WO2010123569) IMMUNONANOTHERAPEUTICS PROVIDING A TH1-BIASED RESPONSE

Pub. No.:    WO/2010/123569    International Application No.:    PCT/US2010/001203
Publication Date: Fri Oct 29 01:59:59 CEST 2010 International Filing Date: Thu Apr 22 01:59:59 CEST 2010
IPC: A61K 47/48
A61P 39/00
Applicants: SELECTA BIOSCIENCES, INC.
LIPFORD, Grayson, B.
BRATZLER, Robert, L.
Inventors: LIPFORD, Grayson, B.
BRATZLER, Robert, L.
Title: IMMUNONANOTHERAPEUTICS PROVIDING A TH1-BIASED RESPONSE
Abstract:
Disclosed are synthetic nanocarrier compositions, and related methods, for treating diseases in which generating a Th1 -biased immune response is desirable. In an aspect, the invention relates to a composition for treatment of a condition comprising: synthetic nanocarriers comprising (1) an immunofeature surface, an (2) a Th1 biasing immunostimulatory agent coupled to the synthetic nanocamers; and a pharmaceutically acceptable excipient; wherein the immunofeature surface does not comprise antigen that is relevant to treatment of the condition in an amount sufficient to provoke an adaptive immune response to the antigen that is relevant to treatment of the condition. In another aspect, the invention relates to a method comprising: identifying a subject suffering from a condition; providing a composition that comprises synthetic nanocarriers that comprise (1) an APC targeting feature, and (2) a Th1 biasing immunostimulatory agent coupled to the synthetic nanocarriers; and a pharmaceutically acceptable excipient; and administering the composition to the subject; wherein the administration of the composition does not further comprise co-administration of an antigen that is relevant to treatment of the condition. In yet another aspect, the invention relates to a method comprising: providing a composition comprising synthetic nanocarriers that comprise a Th1 biasing immunostimulatory agent and an APC targeting feature; administering the composition to a subject; and administering an antigen to the subject to which a Th1 biased response is desired at a time different from administration of the composition to the subject; wherein administration of the antigen comprises passive administration or active administration.