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Pub. No.:    WO/2010/123156    International Application No.:    PCT/JP2010/057735
Publication Date: 28.10.2010 International Filing Date: 23.04.2010
Chapter 2 Demand Filed:    09.02.2011    
A61K 45/00 (2006.01), A61K 31/7105 (2006.01), A61K 31/713 (2006.01), A61K 39/395 (2006.01), A61K 48/00 (2006.01), A61P 9/00 (2006.01), A61P 27/02 (2006.01), A61P 35/00 (2006.01)
Applicants: KAGOSHIMA UNIVERSITY [JP/JP]; 21-24, Korimoto 1-chome, Kagoshima-shi, Kagoshima 8908580 (JP) (For All Designated States Except US).
KOSAI, Kenichiro [JP/JP]; (JP) (For US Only).
SAKAMOTO, Taiji [JP/JP]; (JP) (For US Only).
KAMISASANUKI, Tarou [JP/JP]; (JP) (For US Only)
Inventors: KOSAI, Kenichiro; (JP).
SAKAMOTO, Taiji; (JP).
Agent: HIRAKI, Yusuke; Kamiya-cho MT Bldg. 19F, 3-20, Toranomon 4-chome, Minato-ku, Tokyo 1050001 (JP)
Priority Data:
2009-105170 23.04.2009 JP
(JA) 血管新生抑制剤
Abstract: front page image
(EN)Disclosed is a novel composition which has an effect of inhibiting or preventing angiogenesis, is applicable to the treatment, prevention or recurrence prevention of diseases associated with an angiogenic mechanism such as diabetic retinopathy and age-related macular degeneration, and is an alternative for physical therapies. Specifically disclosed are: an angiogenesis inhibitor comprising an inhibitor of CD9 that belongs to a four transmembrane protein family; and an anti-angiogenic composition comprising the angiogenesis inhibitor.
(FR)L'invention porte sur une nouvelle composition qui a un effet d'inhibition ou de prévention d'une angiogenèse, qui est applicable au traitement, à la prévention ou à la prévention de la récurrence de maladies associées à un mécanisme d'angiogenèse telles qu'une rétinopathie diabétique et une dégénérescence maculaire liée à l'âge, et qui constitue une alternative à des thérapies physiques. L'invention porte particulièrement : sur un inhibiteur d'angiogenèse comportant un inhibiteur de CD9 qui appartient à une famille de protéines à quatre chaînes transmembranaires, et sur une composition anti-angiogenèse comportant l'inhibiteur d'angiogenèse.
(JA)糖尿病網膜症及び加齢黄斑変性等の血管新生機序に関連する疾患の治療、予防又は再発防止に適用するための物理的治療法に替わる血管新生阻害効果又は抑制効果を有する新規の組成物を開発し、提供することを目的とする。 4回膜貫通型タンパク質ファミリーに属するCD9の抑制剤で構成される血管新生抑制剤及び当該血管新生抑制剤を含有する血管新生抑制組成物を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)