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1. (WO2010123150) 2-ARYL IMIDAZOLINE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/123150 International Application No.: PCT/JP2010/057533
Publication Date: 28.10.2010 International Filing Date: 21.04.2010
IPC:
C07D 233/06 (2006.01) ,A61K 31/4174 (2006.01) ,A61P 3/04 (2006.01)
Applicants: HAGA, Yuji[JP/JP]; JP (UsOnly)
MORIYA, Minoru[JP/JP]; JP (UsOnly)
TAKAHASHI, Toshiyuki[JP/JP]; JP (UsOnly)
MSD K.K.[JP/JP]; Kitanomaru Square, 1-13-12 Kudankita, Chiyoda-ku, Tokyo 1028667, JP (AllExceptUS)
Inventors: HAGA, Yuji; JP
MORIYA, Minoru; JP
TAKAHASHI, Toshiyuki; JP
Common
Representative:
MSD K.K.; Kitanomaru Square, 1-13-12 Kudankita, Chiyoda-ku, Tokyo 1028667, JP
Priority Data:
2009-10443622.04.2009JP
Title (EN) 2-ARYL IMIDAZOLINE DERIVATIVES
(FR) DÉRIVÉS DE 2-ARYL IMIDAZOLINE
Abstract: front page image
(EN) 2-Aryl imidazoline derivatives are provided that are useful as anti-obesity agents or the like. A compound represented by Formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each independently represent a hydrogen atom, halogen, C1-6alkyl, or the like; R3a, R3b, R4a and R4b each independently represent a hydrogen atom, C1-6alkyl, or haloC1-6alkyl; and Ar represents aryl, wherein the aryl may be substituted with 1 to 3 substituents such as halogen, cyano, C1-6alkyl, haloC1-6alkyl, C1-6alkyloxy, haloC1-6alkyloxy, hydroxy, amino, monoC1-6alkylamino, diC1-6alkylamino, and C1-6alkyloxycarbonyl.
(FR) L'invention concerne des dérivés de 2-aryl imidazoline qui sont utiles comme agents anti-obésité ou similaire. L'invention porte sur un composé représenté par la Formule (1) ou sur un sel pharmaceutiquement acceptable de celui-ci : dans laquelle R1 et R2 représentent chacun indépendamment un atome d'hydrogène, halogène, alkyle en C1-6 ou similaires ; R3a, R3b, R4a et R4b représentent chacun indépendamment un atome d'hydrogène, alkyle en C1-6, ou halo-alkyle en C1-6 ; et Ar représente aryle, dans lequel l'aryle peut être substitué par 1 à 3 substituants tels qu'halogène, cyano, alkyle en C1-6, halo-alkyle en C1-6, alkyloxy en C1-6, halo- alkyloxy en C1-6, hydroxy, amino, mono-alkyl en C1-6-amino, di(alkyl en C1-6)amino et alkyl en C1-6 oxycarbonyle.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)