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1. (WO2010123139) ARYLCARBOXAMIDE DERIVATIVE HAVING SULFAMOYL GROUP
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/123139    International Application No.:    PCT/JP2010/057397
Publication Date: 28.10.2010 International Filing Date: 26.04.2010
IPC:
A61K 31/167 (2006.01), A61K 31/18 (2006.01), A61K 31/343 (2006.01), A61K 31/353 (2006.01), A61K 31/357 (2006.01), A61K 31/36 (2006.01), A61K 31/40 (2006.01), A61K 31/4025 (2006.01), A61K 31/404 (2006.01), A61K 31/416 (2006.01), A61K 31/4184 (2006.01), A61K 31/423 (2006.01), A61K 31/428 (2006.01), A61K 31/438 (2006.01), A61K 31/4427 (2006.01), A61K 31/4439 (2006.01), A61K 31/445 (2006.01), A61K 31/45 (2006.01), A61K 31/4525 (2006.01), A61K 31/4535 (2006.01), A61K 31/454 (2006.01), A61K 31/4545 (2006.01), A61K 31/47 (2006.01), A61K 31/4704 (2006.01), A61K 31/472 (2006.01), A61K 31/4725 (2006.01), A61K 31/496 (2006.01), A61K 31/498 (2006.01), A61K 31/517 (2006.01), A61K 31/536 (2006.01), A61K 31/5375 (2006.01), A61K 31/5377 (2006.01), A61K 31/538 (2006.01), A61K 31/5415 (2006.01), A61K 31/55 (2006.01), A61K 31/553 (2006.01), A61P 1/16 (2006.01), A61P 3/04 (2006.01), A61P 3/06 (2006.01), A61P 3/10 (2006.01), A61P 9/10 (2006.01), A61P 9/12 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01), C07D 207/08 (2006.01), C07D 207/36 (2006.01), C07D 209/08 (2006.01), C07D 209/30 (2006.01), C07D 209/34 (2006.01), C07D 211/56 (2006.01), C07D 211/60 (2006.01), C07D 211/72 (2006.01), C07D 211/96 (2006.01), C07D 213/40 (2006.01), C07D 213/71 (2006.01), C07D 213/75 (2006.01), C07D 215/20 (2006.01), C07D 215/38 (2006.01), C07D 217/02 (2006.01), C07D 217/06 (2006.01), C07D 217/08 (2006.01), C07D 223/04 (2006.01), C07D 231/56 (2006.01), C07D 235/26 (2006.01), C07D 235/30 (2006.01), C07D 239/80 (2006.01), C07D 241/04 (2006.01), C07D 241/42 (2006.01), C07D 263/56 (2006.01), C07D 263/58 (2006.01), C07D 265/18 (2006.01), C07D 265/36 (2006.01), C07D 267/14 (2006.01), C07D 277/62 (2006.01), C07D 279/02 (2006.01), C07D 295/22 (2006.01), C07D 307/64 (2006.01), C07D 307/79 (2006.01), C07D 311/04 (2006.01), C07D 311/22 (2006.01), C07D 311/74 (2006.01), C07D 317/58 (2006.01), C07D 317/66 (2006.01), C07D 319/18 (2006.01), C07D 319/20 (2006.01), C07D 333/34 (2006.01), C07D 333/38 (2006.01), C07D 401/12 (2006.01), C07D 413/04 (2006.01), C07D 413/12 (2006.01), C07D 491/113 (2006.01), C07C 311/16 (2006.01), C07C 311/20 (2006.01), C07C 317/44 (2006.01)
Applicants: MOCHIDA PHARMACEUTICAL CO., LTD. [JP/JP]; 7, Yotsuya 1-chome, Shinjuku-ku, Tokyo 1608515 (JP) (For All Designated States Except US).
KAMINO Tomoyuki [JP/JP]; (JP) (For US Only).
NAMBA Mutsuo [JP/JP]; (JP) (For US Only).
ASAKURA Toshimichi [JP/JP]; (JP) (For US Only)
Inventors: KAMINO Tomoyuki; (JP).
NAMBA Mutsuo; (JP).
ASAKURA Toshimichi; (JP)
Agent: KOBAYASHI Hiroshi; ABE, IKUBO & KATAYAMA, Fukuoka Bldg. 9th Fl., 8-7, Yaesu 2-chome, Chuo-ku, Tokyo 1040028 (JP)
Priority Data:
2009-107114 24.04.2009 JP
Title (EN) ARYLCARBOXAMIDE DERIVATIVE HAVING SULFAMOYL GROUP
(FR) DÉRIVÉ ARYLCARBOXAMIDE AYANT UN GROUPE SULFAMOYLE
(JA) スルファモイル基を有するアリールカルボキサミド誘導体
Abstract: front page image
(EN)Disclosed is a long-chain fatty acid elongase (Elovl6) inhibitor, which is characterized by comprising at least one of a compound represented by formula (I), a pharmaceutically acceptable salt of the compound, and a solvate of the compound or the pharmaceutically acceptable salt as an active ingredient. Thus, provided is an Elovl6 inhibitor, particularly a prophylactic or therapeutic agent for NAFLD·NASH, diabetes, insulin resistance, obesity/adiposity, or the like.
(FR)L'invention porte sur un inhibiteur d'élongase d'acide gras à chaîne longue (Elov16) qui est caractérisé par le fait qu'il comporte, en tant qu'ingrédient actif, au moins l'un parmi un composé représenté par la formule (I), un sel de qualité pharmaceutique du composé, et un solvate du composé ou du sel de qualité pharmaceutique. Ainsi, l'invention porte sur un inhibiteur de Elov16, particulièrement sur un agent prophylactique ou thérapeutique pour NAFLD·NASH, le diabète, une résistance à l'insuline, une obésité/adiposité ou autre.
(JA)式(I)で表される化合物、または製薬学的に許容されるその塩またはそれらの溶媒和物の少なくともひとつを有効成分として含有することを特徴とする、長鎖脂肪酸伸長酵素(Elovl6)阻害剤。これにより、Elovl6阻害剤、とりわけNAFLD・NASH、糖尿病、インスリン抵抗性、肥満・肥満症等の予防または治療剤の提供がされる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)