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1. (WO2010123119) THERAPEUTIC AGENT AND SCREENING METHOD FOR INFLAMMATORY BOWEL DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/123119    International Application No.:    PCT/JP2010/057289
Publication Date: 28.10.2010 International Filing Date: 23.04.2010
IPC:
A61K 39/395 (2006.01), A61K 45/00 (2006.01), A61P 1/04 (2006.01), A61P 1/06 (2006.01), A61P 1/12 (2006.01), C12Q 1/02 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
Applicants: EISAI R&D MANAGEMENT CO., LTD. [JP/JP]; 6-10, Koishikawa 4-chome, Bunkyo-ku, Tokyo 1128088 (JP) (For All Designated States Except US).
IMAI Toshio; (For US Only).
ARITA Yoshihisa; (For US Only)
Inventors: IMAI Toshio; .
ARITA Yoshihisa;
Agent: TSUJIMARU Koichiro; 301, Bldg. 1, Kyoto Research Park, 134, Chudoji Minami-machi, Shimogyo-ku, Kyoto-shi, Kyoto 6008813 (JP)
Priority Data:
2009-105717 23.04.2009 JP
Title (EN) THERAPEUTIC AGENT AND SCREENING METHOD FOR INFLAMMATORY BOWEL DISEASE
(FR) AGENT THÉRAPEUTIQUE ET MÉTHODE DE CRIBLAGE DES AFFECTIONS INTESTINALES INFLAMMATOIRES
(JA) 炎症性腸疾患治療剤およびそのスクリーニング方法
Abstract: front page image
(EN)Provided is a novel therapeutic agent that can be used in the treatment of inflammatory bowel disease. Said agent is either: an antibody that binds to T-cell adhesion proteins in bone-marrow-derived dendritic cells, or the antigen-binding fragment thereof; or, an antibody that binds to T-cell ligand proteins for T-cell adhesion proteins in bone-marrow-derived dendritic cells, or a composite containing the antigen-binding fragment of said antibody. The aforementioned antibody that binds to T-cell adhesion proteins is preferably an antibody that binds to peptide fragments that comprise the amino acid sequence represented by sequence number 10 excluding the N-terminal signal peptide. The aforementioned antibody that binds to ligand proteins is preferably an antibody that binds to peptide fragments that comprise the amino acid sequence represented by sequence number 16 excluding the N-terminal signal peptide. The abovementioned antigen-binding fragments are preferably antigen-binding fragments of the aforementioned antibodies.
(FR)L'invention porte sur un nouvel agent thérapeutique utilisé dans le traitement des affections intestinales inflammatoires. Ledit agent est: soit un anticorps se fixant aux protéines d'adhésion aux lymphocytes T des cellules dendritiques dérivées de la moelle osseuse, ou l'un de ses fragments se fixant à l'antigène; soit un anticorps se fixant aux protéines de ligands des protéines d'adhésion aux lymphocytes T des cellules dendritiques dérivées de la moelle osseuse ou un composite contenant le fragment se fixant à l'antigène dudit anticorps. Ledit anticorps est de préférence un anticorps se fixant aux fragments de peptides comprenant la séquence d'acides aminés représenté par la séquence numéro 10, en excluant le peptide signal N-terminal. Le susdit anticorps se fixant à des protéines de ligands est de préférence un anticorps se fixant aux fragments de peptides comprenant la séquence d'acides aminés représenté par la séquence numéro 16, en excluant le peptide signal N-terminal. Les susdits fragments de fixant aux antigènes sont de préférence ceux des susdits anticorps.
(JA) 炎症性腸疾患の治療に使用できる新たな治療剤を提供する。 骨髄由来樹状細胞上のT細胞接着タンパク質に結合する抗体もしくはその抗原結合断片、または、骨髄由来樹状細胞上のT細胞接着タンパク質に対するT細胞上のリガンドタンパク質に結合する抗体もしくはその抗原結合断片を含む組成物を炎症性腸疾患剤として提供する。前記T細胞接着タンパク質に結合する抗体もしくはその抗原結合断片は、配列番号10で表わされるアミノ酸配列において、N末端のシグナルペプチドを除くペプチド断片に結合する抗体またはその抗原結合断片が好ましい。前記リガンドタンパク質に結合する抗体もしくはその抗原結合断片は、配列番号16で表わされるアミノ酸配列において、N末端のシグナルペプチドを除くペプチド断片に結合する抗体またはその抗原結合断片が好ましい。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)