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1. (WO2010123017) TETRAZOLE COMPOUND

Pub. No.:    WO/2010/123017    International Application No.:    PCT/JP2010/057035
Publication Date: Fri Oct 29 01:59:59 CEST 2010 International Filing Date: Thu Apr 22 01:59:59 CEST 2010
IPC: C07D 257/04
A61K 31/41
A61K 31/4439
A61K 31/506
A61P 3/10
A61P 43/00
C07D 401/06
C07D 403/12
C07D 405/12
C07D 405/14
Applicants: Astellas Pharma Inc.
アステラス製薬株式会社
NEGORO, Kenji
根来 賢二
OHNUKI, Kei
大貫 圭
YONETOKU, Yasuhiro
米徳 康博
KURAMOTO, Kazuyuki
倉本 和幸
URANO, Yasuharu
浦野 泰治
IWASAKI, Fumiyoshi
岩崎 史良
Inventors: NEGORO, Kenji
根来 賢二
OHNUKI, Kei
大貫 圭
YONETOKU, Yasuhiro
米徳 康博
KURAMOTO, Kazuyuki
倉本 和幸
URANO, Yasuharu
浦野 泰治
IWASAKI, Fumiyoshi
岩崎 史良
Title: TETRAZOLE COMPOUND
Abstract:
Disclosed are: a compound represented by formula (I) or a pharmaceutically acceptable salt thereof; and use of the compound or the pharmaceutically acceptable salt thereof for medical purposes. In the formula, RA2 and RA3 independently represent H, or together form -CH2-C(RX1)(RX2)-; RX1 and RX2 independently represent H, or together form an optionally substituted C2-7 alkylene group. The compound or the pharmaceutically acceptable salt thereof has an excellent GPR40 agonistic activity and can be used for medical purposes, such as an insulin secretion promoter and a prophylactic or therapeutic agent for diabetes.