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Pub. No.:    WO/2010/122385    International Application No.:    PCT/IB2010/000711
Publication Date: 28.10.2010 International Filing Date: 29.03.2010
A61K 38/28 (2006.01), A61K 47/48 (2006.01), A61P 5/50 (2006.01), A61K 47/36 (2006.01)
Applicants: ADOCIA [FR/FR]; 115, avenue Lacassagne F-69003 Lyon (FR) (For All Designated States Except US).
SOULA, Gérard [FR/FR]; (FR) (For US Only).
SOULA, Olivier [FR/FR]; (FR) (For US Only).
SOULA, Rémi [FR/FR]; (FR) (For US Only)
Inventors: SOULA, Gérard; (FR).
SOULA, Olivier; (FR).
SOULA, Rémi; (FR)
Agent: CABINET INES TRIPOZ; 52, rue du Colombier F-69007 Lyon (FR)
Priority Data:
61/202,692 27.03.2009 US
09/01478 27.03.2009 FR
Abstract: front page image
(EN)The invention relates to a complex of insulin and a polysaccharide comprising carboxylic functional groups, said polysaccharide being selected from among the polysaccharides functionalized by at least one phenylalanine derivative, in particular said phenylalanine derivative being selected from the group consisting of phenylalanine and the alkaline cation salts thereof, phenylalanine, phenylalaninamide, amine ethyl benzyl or from among the esters of phenylalanine and said insulin being either a human insulin or equivalent insulin. The invention also relates to a pharmaceutical composition including at least one complex according to the invention, particularly in the form of an injectable solution.
(FR)L'invention concerne un complexe entre une insuline et un polysaccharide comportant des groupes fonctionnels carboxyles, ledit polysaccharide étant choisi parmi les polysaccharides fonctionnalisés par au moins un dérive de Ia phénylalanine, note Phe ledit derive de Ia phénylalanine etant choisi dans Ie groupe constitue par Ia phénylalanine et ses sels de cation alcalin, Ie phénylalanine, Ie phénylalaninamide, I'ethyle benzyle amine ou parmi les esters de Ia phénylalanine et ladite insuline étant soit une insuline humaine soit une insuline analogue. L'invention concerne également une composition pharmaceutique comprenant au moins un complexe selon l'invention, notamment sous forme d'une solution injectable.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)