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1. (WO2010122096) PROCESS FOR OBTAINING FLUOROMETHOLONE AND INTERMEDIATES THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/122096 International Application No.: PCT/EP2010/055333
Publication Date: 28.10.2010 International Filing Date: 22.04.2010
IPC:
C07J 7/00 (2006.01) ,C07J 51/00 (2006.01) ,C07J 71/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
7
Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
51
Normal steroids with unmodified cyclopenta[a]hydrophenanthrene skeleton not provided for in groups C07J1/-C07J43/151
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
71
Steroids in which the cyclopenta[a]hydrophenanthrene skeleton is condensed with a heterocyclic ring
Applicants:
LORENTE BONDE-LARSEN, Antonio [ES/ES]; ES (UsOnly)
IGLESIAS RETUERTO, Jesús Miguel [ES/ES]; ES (UsOnly)
HERRÁIZ SIERRA, Ignacio [ES/ES]; ES (UsOnly)
BERMEJO GONZÁLEZ, Francisco [ES/ES]; ES (UsOnly)
MARCOS ESCRIBANO, José Andres [ES/ES]; ES (UsOnly)
GUTIÉRREZ FUENTES, Luis Gerardo [ES/ES]; ES (UsOnly)
CRYSTAL PHARMA, S.L.U. [ES/ES]; Parque Tecnológico de Boecillo, parcela 105A E-47151 Boecillo - Valladolid, ES (AllExceptUS)
Inventors:
LORENTE BONDE-LARSEN, Antonio; ES
IGLESIAS RETUERTO, Jesús Miguel; ES
HERRÁIZ SIERRA, Ignacio; ES
BERMEJO GONZÁLEZ, Francisco; ES
MARCOS ESCRIBANO, José Andres; ES
GUTIÉRREZ FUENTES, Luis Gerardo; ES
Agent:
ARIAS SANZ, Juan; ABG Patentes, S.L. Avenida de Burgos, 16D Edificio Euromor E-28036 Madrid, ES
Priority Data:
09382055.323.04.2009EP
Title (EN) PROCESS FOR OBTAINING FLUOROMETHOLONE AND INTERMEDIATES THEREFOR
(FR) PROCÉDÉ POUR L'OBTENTION DE FLUOROMÉTHOLONE ET INTERMÉDIAIRES CORRESPONDANTS
Abstract:
(EN) The present invention relates to a process for obtaining compounds of formula (I) and (V), wherein R1 is C1-C6 alkyl; and R2 is OR3, OC(=O)R4 or O-(HPG), wherein R3 is H, C1-C6 alkyl or C6-C14 aryl; R4 is H or C1-C6 alkyl; and HPG is a hydro xyl protecting group, intermediates useful in the synthesis of some steroids, for example, fluorometholone and derivatives thereof. The invention also relates to other intermediates useful in synthesis.
(FR) La présente invention porte sur un procédé pour l'obtention de composés représentés par les formules (I) et (V), dans lesquelles R1 représente alkyle en C1-C6 ; et R2 représente OR3, OC(=O)R4 ou O-(HPG), où R3 représente H, alkyle en C1-C6 ou aryle en C6-C14 ; R4 représente H ou alkyle en C1-C6 ; et HPG représente un groupe protecteur d'hydroxyle, des intermédiaires utiles dans la synthèse de certains stéroïdes, par exemple de fluorométholone et de dérivés de celle-ci. L'invention porte également sur d'autres intermédiaires utiles en synthèse.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)