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1. (WO2010120942) HISTONE MODIFICATION PATTERNS FOR CLINICAL DIAGNOSIS AND PROGNOSIS OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/120942 International Application No.: PCT/US2010/031112
Publication Date: 21.10.2010 International Filing Date: 14.04.2010
IPC:
G01N 33/574 (2006.01) ,C12Q 1/68 (2006.01) ,G01N 33/15 (2006.01) ,A61P 35/00 (2006.01)
Applicants: DAWSON, David W.[US/US]; US (UsOnly)
KURDISTANI, Siavash K.[US/US]; US (UsOnly)
SELIGSON, David B.[US/US]; US (UsOnly)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA[US/US]; 1111 Franklin Street, 12th Floor Oakland, California 94607-5200, US (AllExceptUS)
Inventors: DAWSON, David W.; US
KURDISTANI, Siavash K.; US
SELIGSON, David B.; US
Agent: MYCROFT, Frank J.; Townsend and Townsend and Crew LLP Two Embarcadero Center, Eighth Floor San Francisco, California 94111-3834, US
Priority Data:
61/169,21214.04.2009US
61/169,21614.04.2009US
61/225,16213.07.2009US
Title (EN) HISTONE MODIFICATION PATTERNS FOR CLINICAL DIAGNOSIS AND PROGNOSIS OF CANCER
(FR) MODÈLES DE MODIFICATION DES HISTONES UTILISABLES À DES FINS DE DIAGNOSTIC CLINIQUE ET DE PRONOSTIC EN MATIÈRE DE CANCER
Abstract: front page image
(EN) The present invention provides methods of diagnosing and providing a prognosis and therapy for cancer including, but not limited to, pancreatic cancer and responsiveness to thymidylate synthase inhibitor (e.g., 5-FU) therapy, by identifying cancers with altered histone modification patterns selected from the group consisting of H3K4me2, H3K9me2, or H3K18ac.
(FR) La présente invention concerne des procédés de diagnostic, d'établissement d'un pronostic et de proposition d'un traitement en cas de cancer, par exemple en cas de cancer du pancréas, ainsi qu'un traitement impliquant la sensibilité à des inhibiteurs de la thymidylate synthase (par exemple le 5-FU), et ce en identifiant des cancers associés à des modèles de modification des histones modifiés, choisis dans le groupe constitué de H3K4me2, H3K9me2 ou H3K18ac.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)