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1. (WO2010120861) METHODS OF TREATING CANCERS WITH HER3 ANTISENSE OLIGONUCLEOTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/120861 International Application No.: PCT/US2010/031005
Publication Date: 21.10.2010 International Filing Date: 14.04.2010
IPC:
A61K 31/70 (2006.01) ,C07H 21/04 (2006.01)
Applicants: ZHANG, Yixian[US/US]; US (UsOnly)
QU, Zhengxing[US/US]; US (UsOnly)
GREENBERGER, Lee Martin[US/US]; US (UsOnly)
ENZON PHARMACEUTICALS, INC.[US/US]; 685 Route 202/206 Bridgewater, New Jersey 08807, US (AE, AG, AO, AU, BB, BF, BH, BJ, BR, BW, BZ, CA, CF, CG, CL, CM, CN, CO, CR, CU, DM, DO, DZ, EC, EG, GA, GD, GH, GM, GN, GQ, GT, GW, HN, ID, IL, IN, JP, KE, KM, KN, KP, KR, LA, LC, LK, LR, LS, LY, MA, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PE, PG, PH, SC, SD, SG, SI, SL, SN, ST, SV, SY, SZ, TD, TG, TH, TN, TT, TZ, UG, US, VC, VN, ZA, ZM, ZW)
SANTARIS PHARMA A/S[DK/DK]; Kogle Allé 6 DK 2970 Hoersholm, DK (AllExceptUS)
Inventors: ZHANG, Yixian; US
QU, Zhengxing; US
GREENBERGER, Lee Martin; US
Agent: MERCANTI, Michael N.; Lucas & Mercanti, LLP 475 Park Avenue South 15th Floor New York, New York 10016, US
Priority Data:
61/169,09314.04.2009US
Title (EN) METHODS OF TREATING CANCERS WITH HER3 ANTISENSE OLIGONUCLEOTIDES
(FR) PROCÉDÉS DE TRAITEMENT DE CANCERS AVEC DES OLIGONUCLÉOTIDES ANTISENS DE HER3
Abstract:
(EN) One aspect of the invention provides methods for treating cancers which are resistant to treatment with a protein tyrosine kinase inhibitor by co-treatment with the protein tyrosine kinase inhibitor and one or more antisense oligomers that reduce the expression of HER3 and/or HER2 and/or EGFR. Another aspect of the invention provides methods for treating cancers by co-treatment with an inhibitor of HER2 and one or more antisense oligomers that reduce the expression of HER3.
(FR) Selon un aspect, l'invention porte sur des procédés de traitement de cancers qui sont résistants à un traitement par un inhibiteur de protéine tyrosine kinase, par un co-traitement avec l'inhibiteur de protéine tyrosine kinase et un ou plusieurs oligomères anti-sens qui réduisent l'expression de HER3 et/ou HER2 et/ou EGFR. Un autre aspect de l'invention porte sur des procédés pour traiter des cancers par un co-traitement avec un inhibiteur de HER2 et un ou plusieurs oligomères anti-sens qui réduisent l'expression de HER3.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)