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1. (WO2010120691) METHIONINE SULFOXIDE PEPTIDE, COMPOSITIONS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/120691 International Application No.: PCT/US2010/030749
Publication Date: 21.10.2010 International Filing Date: 12.04.2010
IPC:
A61K 38/08 (2006.01) ,A61K 8/64 (2006.01) ,A61P 17/18 (2006.01) ,A61Q 19/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
64
Proteins; Peptides; Derivatives or degradation products thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
18
Antioxidants, e.g. antiradicals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q
SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19
Preparations for care of the skin
08
Anti-ageing preparations
Applicants: PELLE, Edward[US/US]; US (UsOnly)
MAES, Daniel H.[US/US]; US (UsOnly)
ELC MANAGEMENT LLC[US/US]; 767 Fifth Avenue New York, New York 10153, US (AllExceptUS)
Inventors: PELLE, Edward; US
MAES, Daniel H.; US
Agent: GIANCANA, Peter; Suite 345 South 155 Pinelawn Road Melville, New York 11747, US
Priority Data:
61/168,80813.04.2009US
Title (EN) METHIONINE SULFOXIDE PEPTIDE, COMPOSITIONS AND METHODS OF USE
(FR) PEPTIDE DE MÉTHIONINE SULFOXYDE, COMPOSITIONS ET PROCÉDÉS D'UTILISATION
Abstract:
(EN) Use of a peptide containing an oxidized methionine residue to ameliorate the effects of oxidative stress in human skin. A short polypeptide containing an oxidized methionine at its C-terminus is shown to inhibit the production of Sunburn Cells in living skin models and to upregulate methionine sulfoxide reductase. Cosmetically acceptable compositions and methods of using the polypeptide are disclosed. The oxidized peptide may repair oxidized alpha 1-antitrypsin, which, in turn, inhibits breakdown of connective tissue by elastase. This effect may have wide ranging ramifications, including, for example, repair of sun damaged skin and treatment of emphysema.
(FR) La présente invention concerne l'utilisation d'un peptide contenant un résidu de méthionine oxydée pour améliorer les effets du stress oxydatif sur la peau humaine. Il a été montré qu'un polypeptide court contenant une méthionine oxydée à son extrémité C-terminale inhibe la production de cellules « coup de soleil » dans des modèles de peau vivante et sur‑régule la méthionine sulfoxyde réductase. L'invention concerne des compositions acceptables sur le plan cosmétique et des procédés d'utilisation des polypeptides. Le peptide oxydé peut réparer l'alpha 1-antitrypsine oxydée, qui, à son tour, inhibe la décomposition du tissu conjonctif par l'élastase. Cet effet peut avoir des ramifications étendues, comprenant par exemple, la réparation de peau endommagée par le soleil et le traitement de l'emphysème.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)