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1. (WO2010120592) COMBINATION THERAPY USING AN ANTI-EGFR AGENT(S) AND IGF-1R SPECIFIC INHIBITORS

Pub. No.:    WO/2010/120592    International Application No.:    PCT/US2010/030022
Publication Date: Fri Oct 22 01:59:59 CEST 2010 International Filing Date: Wed Apr 07 01:59:59 CEST 2010
IPC: A61K 39/395
A61K 31/517
Applicants: MERCK SHARP & DOHME CORP.
SATHYANARAYANAN, Sriram
KASIBHATLA, Shailaja
WINTER, Christopher
CHASTAIN, Michael
Inventors: SATHYANARAYANAN, Sriram
KASIBHATLA, Shailaja
WINTER, Christopher
CHASTAIN, Michael
Title: COMBINATION THERAPY USING AN ANTI-EGFR AGENT(S) AND IGF-1R SPECIFIC INHIBITORS
Abstract:
The combination of an IGF-1R antagonist such as a humanized antibody and an anti-proliferative drug is described. In a preferred embodiment, the present invention describes the combination of an IGF-1R antibody and an anti-proliferative drug belonging to the EGFR-inhibitor class, which is preferably erlotinib. The combination according to the present invention is useful for the treatment of tumours, including IGF-1R and /or EGFR mediated or dependent tumours.