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1. (WO2010120554) DETECTING AND TREATING BREAST CANCER RESISTANCE TO EGFR INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/120554 International Application No.: PCT/US2010/029497
Publication Date: 21.10.2010 International Filing Date: 31.03.2010
IPC:
G01N 33/53 (2006.01) ,C07K 16/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
Applicants:
MOONLEE, Sun-Young [KR/KR]; KR (UsOnly)
KENNY, Paraic, A. [IE/US]; US (UsOnly)
LENBURG, Marc, E. [US/US]; US (UsOnly)
XU, Ren [CN/US]; US (UsOnly)
BISSELL, Mina, J. [US/US]; US (UsOnly)
FURUTA, Saori [JP/US]; US (UsOnly)
MEIER, Roland [CH/CH]; CH (UsOnly)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor Oakland, CA 94607-5200, US (AllExceptUS)
Inventors:
MOONLEE, Sun-Young; KR
KENNY, Paraic, A.; US
LENBURG, Marc, E.; US
XU, Ren; US
BISSELL, Mina, J.; US
FURUTA, Saori; US
MEIER, Roland; CH
Agent:
FULLER, Michael, J.; Knobbe Martens Olson & Bear, LLP 2040 Main Street, Fourteenth Floor Irvine, CA 92614, US
Priority Data:
61/165,66801.04.2009US
Title (EN) DETECTING AND TREATING BREAST CANCER RESISTANCE TO EGFR INHIBITORS
(FR) DÉTECTION ET TRAITEMENT DE LA RÉSISTANCE DU CANCER DU SEIN AUX INHIBITEURS D'EGFR
Abstract:
(EN) The application describes therapeutic compositions and methods for treating cancer. For example, therapeutic compositions and methods related to inhibition of FAM83A (family with sequence similarity 83) are provided. The application also describes methods for diagnosing cancer resistance to EGFR inhibitors. For example, a method of diagnosing cancer resistance to EGFR inhibitors by detecting increased FAM83A levels is described.
(FR) La présente invention concerne des compositions thérapeutiques et des procédés destinés au traitement du cancer, et notamment des compositions thérapeutiques et des procédés se rapportant à l'inhibition de FAM83A (famille à similitude avec séquence 83). L'invention concerne également des procédés permettant de diagnostiquer la résistance du cancer aux inhibiteurs d'EGFR (inhibiteurs du récepteur du facteur de croissance de l'épiderme). L'invention concerne ainsi notamment un procédé permettant de diagnostiquer la résistance du cancer aux inhibiteurs d'EGFR par détection d'un accroissement des niveaux de FAM83A.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)