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1. (WO2010120300) PROCESS FOR THE PREPARATION OF (3R)-HYDR0XYBUTYL (3R) -HYDROXYBUTYRATE BY ENZYMATIC ENANTIOSELECTIVE REDUCTION EMPLOYING LACTOBACILLUS BREVIS ALCOHOL DEHYDROGENASE

Pub. No.:    WO/2010/120300    International Application No.:    PCT/US2009/040773
Publication Date: Fri Oct 22 01:59:59 CEST 2010 International Filing Date: Fri Apr 17 01:59:59 CEST 2009
IPC: C12P 7/62
Applicants: ISIS INNOVATION LIMITED
GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES
ROBERTSON, Jeremy
CLARKE, Kieran
VEECH, Richard Lewis
Inventors: ROBERTSON, Jeremy
CLARKE, Kieran
VEECH, Richard Lewis
Title: PROCESS FOR THE PREPARATION OF (3R)-HYDR0XYBUTYL (3R) -HYDROXYBUTYRATE BY ENZYMATIC ENANTIOSELECTIVE REDUCTION EMPLOYING LACTOBACILLUS BREVIS ALCOHOL DEHYDROGENASE
Abstract:
A process for producing a compound which is (3R)-hydroxybutyl (3R)- hydroxybutyrate of formula (I) which process comprises submitting, to enantioselective reduction, a compound of the following formula (II), (III) or (IV).