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1. (WO2010120275) MENTHOL-DERIVATIVE COMPOUNDS AND USE THEREOF AS ORAL AND SYSTEMIC ACTIVE AGENTS

Pub. No.:    WO/2010/120275    International Application No.:    PCT/US2009/039167
Publication Date: Fri Oct 22 01:59:59 CEST 2010 International Filing Date: Thu Apr 02 01:59:59 CEST 2009
IPC: A61K 8/37
A61K 8/41
A61K 8/42
A61Q 11/00
A61K 31/265
A61K 31/27
Applicants: COLGATE-PALMOLIVE COMPANY
TRIVEDI, Harsh, M.
MIKSA, Davide
WORRELL, Cortney
MACIAS, Chanda
XU, Tao
YANG, Ying
HU, Yanan
Inventors: TRIVEDI, Harsh, M.
MIKSA, Davide
WORRELL, Cortney
MACIAS, Chanda
XU, Tao
YANG, Ying
HU, Yanan
Title: MENTHOL-DERIVATIVE COMPOUNDS AND USE THEREOF AS ORAL AND SYSTEMIC ACTIVE AGENTS
Abstract:
The present invention discloses novel uses of specific menthol-derivative compounds of Formula 1, and compositions thereof, for methods of providing oral and systemic health care benefits, and methods of up-regulating or down-regulating periodontal disease metabolites: Formula 1 wherein, X is an oxygen atom or an NH radical; and R is an unsubstituted or substituted aryl or aliphatic radical. In some embodiments, the oral and systemic health care benefits include biofilm anti- attachment, anti-inflammation, anti-oxidant, anti-bone loss, and anti-microbial benefits. In some embodiments, the periodontal disease metabolites correspond to healthy and/or diseased oral status and allow differential diagnosis of oral health.