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1. (WO2010120275) MENTHOL-DERIVATIVE COMPOUNDS AND USE THEREOF AS ORAL AND SYSTEMIC ACTIVE AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/120275    International Application No.:    PCT/US2009/039167
Publication Date: 21.10.2010 International Filing Date: 01.04.2009
IPC:
A61K 8/37 (2006.01), A61K 8/41 (2006.01), A61K 8/42 (2006.01), A61Q 11/00 (2006.01), A61K 31/265 (2006.01), A61K 31/27 (2006.01)
Applicants: COLGATE-PALMOLIVE COMPANY [US/US]; 300 Park Avenue New York, NY 10022 (US) (For All Designated States Except US).
TRIVEDI, Harsh, M. [US/US]; (US) (For US Only).
MIKSA, Davide [HR/US]; (US) (For US Only).
WORRELL, Cortney [US/US]; (US) (For US Only).
MACIAS, Chanda [US/US]; (US) (For US Only).
XU, Tao [US/US]; (US) (For US Only).
YANG, Ying [CN/US]; (US) (For US Only).
HU, Yanan [CN/US]; (US) (For US Only)
Inventors: TRIVEDI, Harsh, M.; (US).
MIKSA, Davide; (US).
WORRELL, Cortney; (US).
MACIAS, Chanda; (US).
XU, Tao; (US).
YANG, Ying; (US).
HU, Yanan; (US)
Agent: TRAUT, Donald, L.; Colgate-Palmolive Company Patent Department 909 River Road Piscataway, NJ 08855 (US)
Priority Data:
Title (EN) MENTHOL-DERIVATIVE COMPOUNDS AND USE THEREOF AS ORAL AND SYSTEMIC ACTIVE AGENTS
(FR) COMPOSÉS DÉRIVÉS DU MENTHOL ET UTILISATIONS ASSOCIÉES COMME PRINCIPES ACTIFS BUCCAUX ET SYSTÉMIQUES
Abstract: front page image
(EN)The present invention discloses novel uses of specific menthol-derivative compounds of Formula 1, and compositions thereof, for methods of providing oral and systemic health care benefits, and methods of up-regulating or down-regulating periodontal disease metabolites: Formula 1 wherein, X is an oxygen atom or an NH radical; and R is an unsubstituted or substituted aryl or aliphatic radical. In some embodiments, the oral and systemic health care benefits include biofilm anti- attachment, anti-inflammation, anti-oxidant, anti-bone loss, and anti-microbial benefits. In some embodiments, the periodontal disease metabolites correspond to healthy and/or diseased oral status and allow differential diagnosis of oral health.
(FR)La présente invention concerne de nouvelles utilisations de composés dérivés du menthol spécifiques de formule 1, et des compositions associées, pour des procédés apportant des bénéfices pour la santé buccale et systémique, et des procédés de sur-régulation ou de sous-régulation de métabolites de parodontopathies : formule 1 dans laquelle X est un atome d'oxygène ou un radical NH ; et R est un radical aryle ou aliphatique non substitué ou substitué. Dans certains modes de réalisation, les bénéfices pour la santé buccale et systémique comprennent des bénéfices anti-fixation du biofilm, anti-inflammatoires, antioxydants, anti-perte osseuse et antibactériens. Dans certains modes de réalisation, les métabolites de parodontopathies correspondent à des états buccaux sains et/ou pathologiques et permettent un diagnostic différentiel de la santé buccale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)