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1. (WO2010120237) IMIDAZOLE SUBSTITUTED PYRIMIDINES USEFUL IN THE TREATMENT OF GLYCOGEN SYNTHASE KINASE 3 RELATED DISORDERS SUCH AS ALZHEIMER'S DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/120237    International Application No.:    PCT/SE2010/050404
Publication Date: 21.10.2010 International Filing Date: 14.04.2010
IPC:
C07D 413/14 (2006.01), A61K 31/5377 (2006.01), A61P 17/14 (2006.01), A61P 25/18 (2006.01), A61P 25/24 (2006.01), A61P 25/28 (2006.01), A61P 27/06 (2006.01), A61P 29/00 (2006.01), A61P 3/10 (2006.01), A61P 35/00 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (For All Designated States Except US).
ARVIDSSON, Per, I [SE/SE]; (SE) (For US Only).
BURROWS, Jeremy, Nicholas [GB/GB]; (GB) (For US Only).
YNGVE, Ulrika [SE/SE]; (SE) (For US Only).
TJERNELD, Erica [SE/SE]; (SE) (For US Only)
Inventors: ARVIDSSON, Per, I; (SE).
BURROWS, Jeremy, Nicholas; (GB).
YNGVE, Ulrika; (SE).
TJERNELD, Erica; (SE)
Agent: ASTRAZENECA INTELLECTUAL PROPERTY; AstraZeneca AB S-151 85 Södertälje (SE)
Priority Data:
61/169,409 15.04.2009 US
Title (EN) IMIDAZOLE SUBSTITUTED PYRIMIDINES USEFUL IN THE TREATMENT OF GLYCOGEN SYNTHASE KINASE 3 RELATED DISORDERS SUCH AS ALZHEIMER'S DISEASE
(FR) PYRIMIDINES SUBSTITUÉES PAR IMIDAZOLE UTILES DANS LE TRAITEMENT DE TROUBLES LIÉS À LA GLYCOGÈNE SYNTHASE KINASE 3, TELS QUE LA MALADIE D'ALZHEIMER
Abstract: front page image
(EN)The present invention relates to a new compound of formula (I) wherein R1 is hydrogen or fluoro; R2 and R3 are independently selected from hydrogen or methyl; or a pharmaceutically acceptable salt thereof, pharmaceutical formulations containing said compound, to the use of said active compound in therapy, to the use for the treatment of conditions associated with glycogen synthase kinase-3 related disorders, such as Alzheimer's disease, as well as for the method of treatment of said disorders, comprising administering to a mammal, including human in need of such treatment, a therapeutically effective amount of said compound.
(FR)La présente invention porte sur un nouveau composé de formule (I) où R1 représente l'hydrogène ou le fluor; R2 et R3 sont indépendamment choisis parmi l'hydrogène ou le méthyle; ou un sel pharmaceutiquement acceptable associé, sur des formulations pharmaceutiques contenant ledit composé, sur l'utilisation dudit composé actif en thérapie, sur son utilisation pour le traitement d'états pathologiques associés à des troubles liés à la glycogène synthase kinase 3, tels que la maladie d'Alzheimer, ainsi que sur la méthode de traitement desdits troubles comprenant l'administration à un mammifère, notamment un humain nécessitant un tel traitement, d'une quantité thérapeutiquement efficace dudit composé.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)