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1. (WO2010119875) FUSED PYRROLOPYRIDINE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/119875 International Application No.: PCT/JP2010/056619
Publication Date: 21.10.2010 International Filing Date: 13.04.2010
IPC:
C07D 471/14 (2006.01) ,A61K 31/437 (2006.01) ,A61K 31/439 (2006.01) ,A61K 31/4545 (2006.01) ,A61K 31/497 (2006.01) ,A61K 31/541 (2006.01) ,A61K 31/55 (2006.01) ,A61P 1/04 (2006.01) ,A61P 1/16 (2006.01) ,A61P 3/10 (2006.01) ,A61P 7/00 (2006.01) ,A61P 9/00 (2006.01) ,A61P 9/10 (2006.01) ,A61P 11/00 (2006.01) ,A61P 11/02 (2006.01) ,A61P 11/06 (2006.01) ,A61P 17/00 (2006.01) ,A61P 17/02 (2006.01) ,A61P 17/04 (2006.01) ,A61P 17/06 (2006.01) ,A61P 17/08 (2006.01) ,A61P 17/10 (2006.01) ,A61P 17/14 (2006.01) ,A61P 19/02 (2006.01) ,A61P 21/04 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/06 (2006.01) ,A61P 25/28 (2006.01) ,A61P 27/02 (2006.01) ,A61P 29/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/02 (2006.01) ,A61P 37/00 (2006.01) ,A61P 37/06 (2006.01) ,A61P 43/00 (2006.01) ,C07D 519/00 (2006.01)
Applicants: SHIRAKAMI, Shohei[JP/JP]; JP (UsOnly)
NAKAJIMA, Yutaka[JP/JP]; JP (UsOnly)
MAEDA, Jun[JP/JP]; JP (UsOnly)
TOMINAGA, Hiroaki[JP/JP]; JP (UsOnly)
YAMAGISHI, Hiroaki[JP/JP]; JP (UsOnly)
HONDO, Takeshi[JP/JP]; JP (UsOnly)
INAMI, Masamichi[JP/JP]; JP (UsOnly)
MORIO, Hiroki[JP/JP]; JP (UsOnly)
INOUE, Takayuki[JP/JP]; JP (UsOnly)
MIZUTANI, Tsuyoshi[JP/JP]; JP (UsOnly)
ISHIOKA, Hiroki[JP/JP]; JP (UsOnly)
Astellas Pharma Inc.[JP/JP]; 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 1038411, JP (AllExceptUS)
Inventors: SHIRAKAMI, Shohei; JP
NAKAJIMA, Yutaka; JP
MAEDA, Jun; JP
TOMINAGA, Hiroaki; JP
YAMAGISHI, Hiroaki; JP
HONDO, Takeshi; JP
INAMI, Masamichi; JP
MORIO, Hiroki; JP
INOUE, Takayuki; JP
MIZUTANI, Tsuyoshi; JP
ISHIOKA, Hiroki; JP
Agent: MORITA, Hiroshi; c/o Astellas Pharma Inc. Intellectual Property, 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 1038411, JP
Priority Data:
2009-09797414.04.2009JP
Title (EN) FUSED PYRROLOPYRIDINE DERIVATIVE
(FR) DÉRIVÉ DE PYRROLOPYRIDINE CONDENSÉ
(JA) 縮合ピロロピリジン誘導体
Abstract:
(EN) Disclosed is a fused pyrrolopyridine derivative which is useful as an active ingredient for a pharmaceutical composition, in particular a pharmaceutical composition for prevention or treatment of diseases that are caused by undesirable cytokine signaling or diseases that are caused by abnormal cytokine signaling. The inventors have intensively studied on compounds having JAK inhibitory activity, and found that the compound of the present invention, namely a fused pyrrolopyridine derivative has excellent JAK inhibitory activity and is thus useful as an agent for prevention or treatment of diseases that are caused by undesirable cytokine signaling or diseases that are caused by abnormal cytokine signaling.
(FR) La présente invention a pour objet un dérivé de pyrrolopyridine condensé qui est utile en tant qu'ingrédient actif pour une composition pharmaceutique, en particulier une composition pharmaceutique destinée à la prévention ou au traitement de maladies qui sont provoquées par une signalisation indésirable de la cytokine ou de maladies qui sont provoquées par une signalisation anormale de la cytokine. Les inventeurs ont étudié de manière approfondie des composés ayant une activité inhibitrice de JAK, et ont découvert que le composé de la présente invention, à savoir un dérivé de pyrrolopyridine condensé, présentait une excellente activité inhibitrice de JAK et était ainsi utile en tant qu'agent destiné à la prévention ou au traitement de maladies qui sont provoquées par une signalisation indésirable de la cytokine ou de maladies qui sont provoquées par une signalisation anormale de la cytokine.
(JA) 【課題】 本発明は医薬組成物、殊に、望ましくないサイトカインシグナル伝達によって引き起こされる疾患、あるいは異常なサイトカインシグナル伝達によって引き起こされる疾患の予防用若しくは治療用医薬組成物の有効成分として有用な縮合ピロロピリジン誘導体を提供する。 【課題を解決するための手段】 本発明者らは、JAK阻害作用を有する化合物について鋭意検討した結果、本発明化合物である縮合ピロロピリジン誘導体が優れたJAK阻害作用を有し、望ましくないサイトカインシグナル伝達によって引き起こされる疾患、あるいは異常なサイトカインシグナル伝達によって引き起こされる疾患の予防若しくは治療剤として有用であることを見出して本発明を完成した。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)