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1. (WO2010119828) METHOD FOR CULTURING BONE MARROW STROMAL CELLS AND MESENCHYMAL STEM CELLS, AND METHOD FOR PRODUCING GRAFT CELLS FOR TREATING CENTRAL NEUROLOGICAL DISEASE

Pub. No.:    WO/2010/119828    International Application No.:    PCT/JP2010/056503
Publication Date: Fri Oct 22 01:59:59 CEST 2010 International Filing Date: Tue Apr 13 01:59:59 CEST 2010
IPC: C12N 5/0775
A61K 35/28
A61L 27/00
A61P 25/00
C12N 5/077
C12M 1/10
C12N 15/12
C12Q 1/68
Applicants: MITSUBISHI HEAVY INDUSTRIES, LTD.
三菱重工業株式会社
OCHIAI Toshimasa
落合 俊昌
YUGE Louis
弓削 類
KAWAHARA Yumi
河原 裕美
Inventors: OCHIAI Toshimasa
落合 俊昌
YUGE Louis
弓削 類
KAWAHARA Yumi
河原 裕美
Title: METHOD FOR CULTURING BONE MARROW STROMAL CELLS AND MESENCHYMAL STEM CELLS, AND METHOD FOR PRODUCING GRAFT CELLS FOR TREATING CENTRAL NEUROLOGICAL DISEASE
Abstract:
Disclosed is a culture method whereby bone marrow stromal cells or mesenchymal stem cells are cultured in a pseudo-microgravity environment, which has been obtained by multi-axis rotation, to give bone marrow stromal cells or mesenchymal stem cells having a smaller average cell size than the average cell size of the cells before the culture. The bone marrow stromal cells or mesenchymal stem cells having been cultured by the aforesaid culture method are suitable as graft cells for treating a central neurological disease.