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1. (WO2010119583) POLYMER-NUCLEIC ACID COMPLEX, METHOD FOR IMAGING TUMOR CELLS OR THE LIKE USING SAME, AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/119583 International Application No.: PCT/JP2009/068155
Publication Date: 21.10.2010 International Filing Date: 15.10.2009
IPC:
C07K 7/06 (2006.01) ,A61K 38/00 (2006.01) ,A61K 48/00 (2006.01) ,A61K 49/00 (2006.01) ,A61P 35/00 (2006.01) ,C12N 15/09 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
片山佳樹 KATAYAMA, Yoshiki [JP/JP]; JP (UsOnly)
姜貞勲 KANG, Jeong-Hun [KR/JP]; JP (UsOnly)
戸井田力 TOITA, Riki [JP/JP]; JP (UsOnly)
国立大学法人九州大学 KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION [JP/JP]; 福岡県福岡市東区箱崎六丁目10番1号 10-1, Hakozaki 6-chome, Higashi-ku, Fukuoka-shi, Fukuoka 8128581, JP (AllExceptUS)
Inventors:
片山佳樹 KATAYAMA, Yoshiki; JP
姜貞勲 KANG, Jeong-Hun; JP
戸井田力 TOITA, Riki; JP
Agent:
小林浩 KOBAYASHI, Hiroshi; 東京都中央区八重洲二丁目8番7号福岡ビル9階 阿部・井窪・片山法律事務所 ABE, IKUBO & KATAYAMA, Fukuoka Bldg. 9th Fl., 8-7, Yaesu 2-chome, Chuo-ku, Tokyo 1040028, JP
Priority Data:
2009-10139117.04.2009JP
Title (EN) POLYMER-NUCLEIC ACID COMPLEX, METHOD FOR IMAGING TUMOR CELLS OR THE LIKE USING SAME, AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER
(FR) COMPLEXE POLYMÈRE-ACIDE NUCLÉIQUE, PROCÉDÉ D'IMAGERIE DE CELLULES TUMORALES OU SIMILAIRES UTILISANT CELUI-CI ET COMPOSITION PHARMACEUTIQUE POUR LE TRAITEMENT DU CANCER
(JA) ポリマー-核酸複合体、並びにこれを用いた腫瘍細胞等のイメージング方法及び癌の治療用医薬組成物
Abstract:
(EN) Disclosed are: a gene carrier for the tumor cell-specific expression of a target gene; a method for imaging tumor cells or a tumor structure using the gene carrier; and a pharmaceutical composition for the treatment of cancer. Specifically disclosed is a cationic polymer which serves as a gene carrier and is characterized by containing a cationic peptide portion, which serves as a substrate of an enzyme that is specifically expressed in tumor cells, and a hydrophilic polymer portion.
(FR) L'invention porte sur un porteur de gène pour l'expression spécifique de cellules tumorales d'un gène cible ; sur un procédé d'imagerie de cellules tumorales ou d'une structure tumorale à l'aide du porteur de gène ; et sur une composition pharmaceutique pour le traitement du cancer. De façon spécifique, l'invention porte sur un polymère cationique qui sert de porteur de gène et qui est caractérisé par le fait qu'il contient une partie de peptide cationique, lequel sert de substrat pour une enzyme qui est spécifiquement exprimé dans des cellules tumorales, et une partie de polymère hydrophile.
(JA)  本発明は、腫瘍細胞特異的に目的遺伝子を発現させるための遺伝子キャリアや、それを用いた腫瘍細胞又は腫瘍組織のイメージング方法、及び癌の治療用医薬組成物を提供する。本発明の遺伝子キャリアとしてのカチオン性ポリマーは、腫瘍細胞特異的に発現する酵素の基質となり且つカチオン性を有するペプチド部分と、親水性ポリマー部分とを含むことを特徴とするものである。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)