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1. (WO2010119264) IMIDAZOPYRAZINES FOR USE AS KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/119264 International Application No.: PCT/GB2010/000773
Publication Date: 21.10.2010 International Filing Date: 16.04.2010
IPC:
C07D 487/04 (2006.01) ,A61K 31/4985 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/00 (2006.01)
Applicants: PASTOR FERNÁNDEZ, Joaquín[ES/ES]; ES (UsOnly)
MARTÍNEZ GONZÁLEZ, Sonia[ES/ES]; ES (UsOnly)
OYARZABAL SANTAMARINA, Julen[ES/ES]; ES (UsOnly)
CENTRO NACIONAL DE INVESTIGACIONES ONCÓLOGICAS (CNIO)[ES/ES]; Melchor Fernández Almagro 3 E-28029 Madrid, ES (AllExceptUS)
Inventors: PASTOR FERNÁNDEZ, Joaquín; ES
MARTÍNEZ GONZÁLEZ, Sonia; ES
OYARZABAL SANTAMARINA, Julen; ES
Agent: MCNEENEY, Stephen; Potter Clarkson LLP Park View House 58 The Ropewalk Nottingham NG1 5DD, GB
Priority Data:
09380079.516.04.2009EP
Title (EN) IMIDAZOPYRAZINES FOR USE AS KINASE INHIBITORS
(FR) IMIDAZOPYRAZINES POUR UNE UTILISATION EN TANT QU'INHIBITEURS DE KINASE
Abstract: front page image
(EN) There is provided compounds of formula (I), wherein R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
(FR) L'invention porte sur des composés de formule I, où R1, R2, R3, R4 et R5 ont les significations données dans la description, et sur des esters, des amides, des solvates ou des sels pharmaceutiquement acceptables de ceux-ci, lesquels composés sont utiles dans le traitement de maladies dans lesquelles une inhibition d'une protéine kinase ou d'une lipide kinase (par exemple une PI3-K et/ou mTOR) est désirée et/ou nécessaire, et particulièrement dans le traitement d'un cancer ou d'une maladie proliférative.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)