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1. (WO2010118997) PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/118997 International Application No.: PCT/EP2010/054732
Publication Date: 21.10.2010 International Filing Date: 09.04.2010
IPC:
C07D 209/12 (2006.01)
Applicants: JOSHI, Shreerang[IN/IN]; IN (UsOnly)
BHUTA, Sachin[IN/IN]; IN (UsOnly)
TALUKDAR, Sanjay[IN/IN]; IN (UsOnly)
SAWANT, Sudhir[IN/IN]; IN (UsOnly)
VENKATRAMAN, Deepak[IN/IN]; IN (UsOnly)
SANDOZ AG[CH/CH]; Lichtstrasse 35 CH-4056 Basel, CH (AllExceptUS)
Inventors: JOSHI, Shreerang; IN
BHUTA, Sachin; IN
TALUKDAR, Sanjay; IN
SAWANT, Sudhir; IN
VENKATRAMAN, Deepak; IN
Agent: WICHMANN, Hendrik; Wuesthoff & Wuesthoff Schweigerstrasse 2 81541 München, DE
Priority Data:
1419//MUM/200912.06.2009IN
970/MUM/200913.04.2009IN
Title (EN) PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF
(FR) PROCÉDÉS POUR LA SYNTHÈSE D'ACÉTATE DE BAZÉDOXIFÈNE ET INTERMÉDIAIRES CORRESPONDANTS
Abstract: front page image
(EN) Efficient processes for the synthesis of pharmaceutically useful compounds such as (1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1 H-indol-5-ol acetic acid commonly known as bazedoxifene acetate (Formula IX) using cyanomethoxybenzyl halides of Formula III, where X = Halogens e.g., Cl, F, Br, I; G = Any electron donating or electron withdrawing substituent.
(FR) L'invention porte sur des procédés efficaces pour la synthèse de composés pharmaceutiquement utiles tels que l'acide (1-[4-(2-azépan-1-yléthoxy)-benzyl]-2-(4-hydroxyphényl)-3-méthyl-1H-indol-5-olacétique, communément appelé acétate de bazédoxifène (Formule IX), à l'aide d'halogénure de cyanométhoxybenzyle de Formule III, où X = des halogènes, par exemple Cl, F, Br, I; G = n'importe quel substituant donneur d'électrons ou attracteur d'électrons.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)