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1. (WO2010118675) NEW USE OF NEFERINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/118675    International Application No.:    PCT/CN2010/071721
Publication Date: 21.10.2010 International Filing Date: 13.04.2010
Chapter 2 Demand Filed:    15.10.2010    
IPC:
A61K 31/4709 (2006.01), A61K 9/08 (2006.01), A61K 9/14 (2006.01), A61K 9/70 (2006.01), A61P 1/04 (2006.01), A61P 1/18 (2006.01), A61P 3/10 (2006.01), A61P 11/02 (2006.01), A61P 11/06 (2006.01), A61P 11/14 (2006.01), A61P 13/10 (2006.01), A61P 19/02 (2006.01), A61P 21/04 (2006.01), A61P 25/06 (2006.01), A61P 25/16 (2006.01), A61P 25/18 (2006.01), A61P 29/00 (2006.01), A61P 35/04 (2006.01), A61P 37/08 (2006.01)
Applicants: INSTITUTE OF CHINESE MATERIA MEDICA, CHINA ACADEMY OF CHINESE MEDICAL SCIENCES [CN/CN]; 16 Nanxiaojie street, Dongzhimen Nei, Dongcheng District Beijing 100700 (CN) (For All Designated States Except US).
JIANG, Tingliang [CN/CN]; (CN) (For US Only).
SUI, Feng [CN/CN]; (CN) (For US Only).
HUO, Hairu [CN/CN]; (CN) (For US Only).
LI, Lanfang [CN/CN]; (CN) (For US Only).
GUO, Shuying [CN/CN]; (CN) (For US Only)
Inventors: JIANG, Tingliang; (CN).
SUI, Feng; (CN).
HUO, Hairu; (CN).
LI, Lanfang; (CN).
GUO, Shuying; (CN)
Agent: GE CHENG & CO., LTD.; Level 19, Tower E3, The Towers, Oriental Plaza No.1 East Chang An Avenue, Dongcheng District Beijing 100738 (CN)
Priority Data:
200910082318.8 14.04.2009 CN
Title (EN) NEW USE OF NEFERINE
(FR) NOUVELLE UTILISATION DE LA NÉFÉRINE
(ZH) 甲基莲心碱的新用途
Abstract: front page image
(EN)The present invention reveals a new use of neferine. Neferine regulates M8 and V1 subtype of transient receptor potential ion channel (TRPM8 and TRPV1), respectively, in mammals, including humans, and can be used for preparing medicaments for treating diseases related to said ion channel (such as hypercryalgesia, Parkinson's disease, painful bladder syndrome, chronic obstructive pulmonary disease, and tumor of skin, prostate, mammary gland, lung, colon, etc.). The potency of neferine in the present invention is higher than that of hexahydrothymol.
(FR)La présente invention concerne une nouvelle utilisation de la néférine. La néférine régule le sous-type M8 et V1 de canal ionique à potentiel de récepteur transitoire (TRPM8 et TRPV1 en abrégé) respectivement chez des mammifères comprenant un humain, et peut être utilisée pour préparer des médicaments pour traiter des maladies associées audit canal ionique (telles que l'hypercryalgésie, la maladie de Parkinson, le syndrome de la vessie douloureuse, la bronchopneumopathie chronique obstructive, et une tumeur de la peau, de la prostate, des glandes mammaires, du poumon, du côlon, etc.). L'activité de la néférine de la présente invention est supérieure à celle de l'hexahydrothymol.
(ZH)本发明披露了甲基莲心碱的新用途。甲基莲心碱分别调节哺乳动物包括人的M8和V1亚型瞬变受体电位离子通道(简称TRPM8和TRPV1),用于制备所述离子通道参与的相关疾病(如冷痛觉过敏、巴金森氏症、疼痛性膀胱综合症、慢性阻塞性肺疾患等以及皮肤、前列腺、乳腺、肺、结肠的肿瘤等)的药物。本发明的甲基莲心碱的作用强度高于薄荷醇。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)