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1. (WO2010118271) PREPARATION OF SATURATED KETONE MORPHINAN COMPOUNDS BY CATALYTIC ISOMERIZATION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/118271 International Application No.: PCT/US2010/030448
Publication Date: 14.10.2010 International Filing Date: 09.04.2010
IPC:
C07D 489/02 (2006.01) ,C07D 489/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
489
Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
02
with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
489
Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
02
with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
04
Salts; Organic complexes
Applicants:
WANG, Peter, X. [US/US]; US (UsOnly)
JIANG, Tao [CN/US]; US (UsOnly)
BERBERICH, David, W. [US/US]; US (UsOnly)
MALLINCKRODT LLC [US/US]; 675 McDonnell Boulevard Hazelwood, Missouri 63042, US (AllExceptUS)
Inventors:
WANG, Peter, X.; US
JIANG, Tao; US
BERBERICH, David, W.; US
Agent:
SIMAN, Craig, D.; Mallinckrodt LLC 675 McDonnell Boulevard Hazelwood, Missouri 63042, US
Priority Data:
61/167,87609.04.2009US
Title (EN) PREPARATION OF SATURATED KETONE MORPHINAN COMPOUNDS BY CATALYTIC ISOMERIZATION
(FR) PRÉPARATION DE COMPOSÉS CÉTONE SATURÉE MORPHINANES PAR ISOMÉRISATION CATALYTIQUE
Abstract:
(EN) The present invention provides processes for the preparation of saturated ketone morphinan compounds by catalytic isomerization. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an allyl-transition metal catalyst. Formulae (I) and (II).
(FR) La présente invention porte sur des procédés pour la préparation de composés cétone saturée morphinanes par isomérisation catalytique. En particulier, l'invention porte sur des procédés pour la conversion d'un morphinane comprenant une fraction cyclique alcool allylique en un morphinane comprenant une fraction cyclique cétone saturée par une réaction d'isomérisation catalysée par un catalyseur alkyl-métal de transition. (i) (II).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)