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Pub. No.: WO/2010/118241 International Application No.: PCT/US2010/030409
Publication Date: 14.10.2010 International Filing Date: 08.04.2010
IPC:
A01N 37/12 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
37
Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
12
containing the group , wherein Cn means a carbon skeleton not containing a ring; Thio-analogues thereof
Applicants: ZHANG, Zhong-yin[US/US]; US (UsOnly)
ZHANG, Sheng[CN/US]; US (UsOnly)
INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION[US/US]; Office Of Technology Transfer 351 West 10th Street Indianapolis, IN 46202, US (AllExceptUS)
Inventors: ZHANG, Zhong-yin; US
ZHANG, Sheng; US
Agent: EMANUELE, John, J.; Baker & Daniels LLP 300 North Meridian Street Suite 2700 Indianapolis, IN 46204, US
Priority Data:
61/167,62708.04.2009US
Title (EN) INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES
(FR) INHIBITEURS DES PROTÉINE-TYROSINE PHOSPHATASES
Abstract:
(EN) Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC- PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
(FR) Cette invention concerne des composés qui inhibent sélectivement les membres de la famille enzymatique des protéine-tyrosine phosphatases (PTP). Les composés synthétisés démontrent une inhibition sélective des TC-PTP. L'invention concerne également des méthodes d'utilisation de ces composés et des préparations contenant ces composés. L'invention concerne par ailleurs la synthèse d'une bibliothèque combinatoire à marquage fluorescent et une méthode de criblage. L'invention concerne en outre des méthodes d'utilisation de ces composés pour obtenir une activité enzymatique dans les cellules et in vitro, ainsi qu'une méthode d'utilisation de ces composés pour traiter des maladies chez l'homme et l'animal.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)