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1. (WO2010118232) CONTROLLED-RELEASE CLOZAPINE COMPOSITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/118232 International Application No.: PCT/US2010/030393
Publication Date: 14.10.2010 International Filing Date: 08.04.2010
IPC:
A61K 31/553 (2006.01) ,A61K 31/554 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
553
having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
554
having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
Applicants: RUDDY, Stephen, B.[US/US]; US (UsOnly)
MCGURK, Simon, L.[GB/US]; US (UsOnly)
PATEL, Rakesh[IN/US]; US (UsOnly)
BULLOCK, John[US/US]; US (UsOnly)
KEWALRAMANI, Raj[US/US]; US (UsOnly)
ALKERMES PHARMA IRELAND LIMITED[IE/IE]; Monksland, Athlone County Westmeath, IE (AllExceptUS)
Inventors: RUDDY, Stephen, B.; US
MCGURK, Simon, L.; US
PATEL, Rakesh; US
BULLOCK, John; US
KEWALRAMANI, Raj; US
Agent: RACHINSKY, Tara, L.; Fox Rothschild LLP (Elan Pharma) 997 Lenox Drive Building 3 Lawrenceville, NJ 08648-2311, US
Priority Data:
61/168,04009.04.2009US
Title (EN) CONTROLLED-RELEASE CLOZAPINE COMPOSITIONS
(FR) COMPOSITIONS DE CLOZAPINE À LIBÉRATION CONTRÔLÉE
Abstract:
(EN) A composition for delivery of a drug is disclosed. The composition has a semipermeable coating, particles of clozapine having an effective average particle size of less than or about 2 μm and at least one surface stabilizer adsorbed on the surface of the clozapine particles, and a solubilizing agent.
(FR) L'invention porte sur une composition d'administration d'un médicament. La composition comporte un revêtement semi-perméable, des particules de clozapine présentant une dimension de particule moyenne efficace inférieure ou égale à 2 µm et au moins un stabilisant de surface absorbé sur la surface des particules de clozapine et un agent de solubilisation.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)