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1. WO2010118207 - PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS

Publication Number WO/2010/118207
Publication Date 14.10.2010
International Application No. PCT/US2010/030350
International Filing Date 08.04.2010
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
A61P 37/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
Applicants
  • SCHERING CORPORATION [US]/[US] (AllExceptUS)
  • DENG, Yongqi [US]/[US] (UsOnly)
  • SUN, Binyuan [CN]/[US] (UsOnly)
  • ZENG, Hongbo [CN]/[US] (UsOnly)
  • RICHARDS, Matthew [US]/[US] (UsOnly)
  • SHIPPS, Gerald, W., Jr. [US]/[US] (UsOnly)
  • CHENG, Cliff, C. [CN]/[US] (UsOnly)
  • ZHAO, Yinyan [CN]/[US] (UsOnly)
  • MCRINER, Andrew [GB]/[US] (UsOnly)
  • MENG, Zhaoyang [CN]/[US] (UsOnly)
  • NAN, Yang [US]/[US] (UsOnly)
  • PATEL, Mehul, F. [US]/[US] (UsOnly)
  • WRONA, Iwona, E. [US]/[US] (UsOnly)
  • REDDY, Panduranga, Adulla [US]/[US] (UsOnly)
  • EKLOV, Brian, M. [US]/[US] (UsOnly)
  • TANG, Shuyi [CN]/[US] (UsOnly)
  • LIU, Duan [CN]/[US] (UsOnly)
  • MANDAL, Amit, K. [IN]/[US] (UsOnly)
  • ZHAO, Lianyun [CN]/[US] (UsOnly)
  • SIDDIQUI, M., Arshad [CA]/[US] (UsOnly)
Inventors
  • DENG, Yongqi
  • SUN, Binyuan
  • ZENG, Hongbo
  • RICHARDS, Matthew
  • SHIPPS, Gerald, W., Jr.
  • CHENG, Cliff, C.
  • ZHAO, Yinyan
  • MCRINER, Andrew
  • MENG, Zhaoyang
  • NAN, Yang
  • PATEL, Mehul, F.
  • WRONA, Iwona, E.
  • REDDY, Panduranga, Adulla
  • EKLOV, Brian, M.
  • TANG, Shuyi
  • LIU, Duan
  • MANDAL, Amit, K.
  • ZHAO, Lianyun
  • SIDDIQUI, M., Arshad
Agents
  • SU, Li
Priority Data
61/168,09309.04.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS
(FR) DÉRIVÉS PYRAZOLO[1, 5-A]PYRIMIDINE EN TANT QU'INHIBITEURS DE MTOR
Abstract
(EN)
The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds.
(FR)
La présente invention porte sur des procédés d'inhibition de mTOR à l'aide de composés pyrazolo[1, 5-A]pyrimidine et sur des procédés de traitement, de prévention, d'inhibition ou d'amélioration d'une ou plusieurs maladies associées à mTOR à l'aide de tels composés.
Also published as
Latest bibliographic data on file with the International Bureau