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Machine translation
1. (WO2010118166) METHODS OF PREDICTING CANCER RISK USING GENE EXPRESSION IN PREMALIGNANT TISSUE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/118166    International Application No.:    PCT/US2010/030285
Publication Date: 14.10.2010 International Filing Date: 07.04.2010
IPC:
C12Q 1/68 (2006.01)
Applicants: GENOMIC HEALTH INC. [US/US]; 301 Penobscot Drive Redwood City, California 94063 (US) (For All Designated States Except US).
COWENS, Wayne [US/US]; (US) (For US Only).
CRONIN, Maureen T. [US/US]; (US) (For US Only).
MILLWARD, Carl L. [US/US]; (US) (For US Only).
COLLIN, François [US/US]; (US) (For US Only).
CRAGER, Michael [US/US]; (US) (For US Only)
Inventors: COWENS, Wayne; (US).
CRONIN, Maureen T.; (US).
MILLWARD, Carl L.; (US).
COLLIN, François; (US).
CRAGER, Michael; (US)
Agent: FRANCIS, Carol L.; 1900 University Avenue Suite 200 East Palo Alto, California 94303 (US)
Priority Data:
61/167,503 07.04.2009 US
61/243,708 18.09.2009 US
Title (EN) METHODS OF PREDICTING CANCER RISK USING GENE EXPRESSION IN PREMALIGNANT TISSUE
(FR) MÉTHODES DE PRÉVISION DU RISQUE D'UN CANCER UTILISANT L'EXPRESSION GÉNÉTIQUE DANS UN TISSU PRÉCANCÉREUX
Abstract: front page image
(EN)The present disclosure provides methods for assessing a patient's cancer risk and/or recurrence risk, which methods comprise assaying, in a biological sample obtained from the gastrointestinal (GI) tract of the patient, an expression level of a risk gene. The present disclosure also provides methods involving a cancer risk/recurrence risk sequence, i.e. the V600E mutation of the BRAF gene, which is useful for assessing cancer risk and/or recurrence risk in a patient.
(FR)Cette invention concerne des méthodes permettant d'évaluer le risque de survenue et/ou de récidive d'un cancer chez un patient, lesdites méthodes consistant à doser, dans un échantillon biologique prélevé dans le tractus gastro-intestinal (GI) du patient, le taux d'expression d'un gène indicateur de risque. L'invention concerne également des méthodes impliquant une séquence indicatrice du risque de survenue/récidive d'un cancer, à savoir la mutation V600E du gène BRAF, qui est utilisée pour évaluer le risque de survenue et/ou de récidive d'un cancer chez un patient.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)