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1. (WO2010118050) USE OF IMPROVED TOLUIDINE BLUE IN PHOTODYNAMIC THERAPY

Pub. No.:    WO/2010/118050    International Application No.:    PCT/US2010/030125
Publication Date: Fri Oct 15 01:59:59 CEST 2010 International Filing Date: Wed Apr 07 01:59:59 CEST 2010
IPC: A61N 5/067
A61K 9/127
Applicants: ZILA, INC.
BRIDE, Mark
SIEGEL, Hal
Inventors: BRIDE, Mark
SIEGEL, Hal
Title: USE OF IMPROVED TOLUIDINE BLUE IN PHOTODYNAMIC THERAPY
Abstract:
A method of treating oral cancer is provided. The method comprises the steps of providing at least one photodynamic treatment comprising the steps of (i) applying a composition comprising improved toluidine blue to oral cells; wherein the composition comprises a greater percentage by weight of the conformational isomers of toluidine blue compared to the N-demethylated derivatives thereof; and wherein the composition localizes to oral cancer cells,- and activating the applied composition, thereby killing the oral cancer cells.