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1. (WO2010117984) NOVEL STRATEGIES FOR IMPROVED CANCER VACCINES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/117984 International Application No.: PCT/US2010/030045
Publication Date: 14.10.2010 International Filing Date: 06.04.2010
IPC:
A61K 51/00 (2006.01) ,A61K 39/00 (2006.01) ,C12P 21/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
Applicants: CHANG, Chien-Hsing[US/US]; US (UsOnly)
GOLDENBERG, David M.[US/US]; US (UsOnly)
IMMUNOMEDICS, INC.[US/US]; 300 American Road Morris Plains, New Jersey 07950, US (AllExceptUS)
Inventors: CHANG, Chien-Hsing; US
GOLDENBERG, David M.; US
Agent: NAKASHIMA, Richard A.; 300 American Road Morris Plains, New Jersey 07950, US
Priority Data:
12/544,47620.08.2009US
61/168,29010.04.2009US
Title (EN) NOVEL STRATEGIES FOR IMPROVED CANCER VACCINES
(FR) NOUVELLES STRATÉGIES D'AMÉLIORATION DES VACCINS ANTICANCÉREUX
Abstract:
(EN) Methods and compositions for forming anti-cancer vaccine complexes are disclosed The vaccine complex comprises an antibody moiety that binds to dendritic cells, such as an antι-CD74 antibody or antigen-binding fragment thereof, attached to an AD (anchoring domain) moiety and a xenoantigen, such as CD20, attached to a DDD (dimerization and docking domain) moiety, wherein two copies of the DDD moiety form a dimer that binds to the AD moiety, resulting in the formation of the vaccine complex The vaccine complex is capable of inducing an immune response against xenoantigen expressing cancer cells, such as CD13S sub neg CD20+ MM stem cells, and inducing apoptosis of and inhibiting the growth of or eliminating the cancer cells
(FR) Cette invention concerne des méthodes et des compositions permettant de former des complexes de vaccins anticancéreux. Dans des modes de réalisation préférés, le complexe de vaccin anticancéreux comprend une fraction d'anticorps qui se fixe aux cellules dendritiques, par exemple un anticorps anti-CD74 ou son fragment Fab, attachée à une fraction AD (domaine d'ancrage) et un xénoantigène, par exemple le CD20, fixés à une fraction DDD (domaine de dimérisation et d'accouplage); deux copies de la fraction DDD forment un dimère qui se fixe à la fraction AD, ce qui aboutit à la formation du complexe de vaccin. Ce complexe de vaccin anticancéreux est capable d'induire une réponse immunitaire vis-à-vis des cellules cancéreuses exprimant le xénoantigène, par exemple les cellules souches CD138negCD20+ MM, et d'induire l'apoptose des cellules cancéreuses, d'inhiber leur croissance ou de les éliminer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)