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1. (WO2010117829) DIFFERENTIALLY EXPRESSED MICRORNAS AS BIOMARKERS FOR THE DIAGNOSIS AND TREATMENT OF SJÖGREN'S SYNDROME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/117829 International Application No.: PCT/US2010/029307
Publication Date: 14.10.2010 International Filing Date: 31.03.2010
IPC:
C12Q 1/68 (2006.01) ,C12N 15/11 (2006.01) ,A61K 31/7105 (2006.01) ,A61K 48/00 (2006.01) ,A61P 37/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
7105
Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
Applicants:
ALEVIZOS, Ilias [GR/US]; US (UsOnly)
ILLEI, Gabor [HU/US]; US (UsOnly)
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer 6011 Executive Blvd. Suite 325 Msc 7660 Bethesda, MD 20892-7660, US (AllExceptUS)
Inventors:
ALEVIZOS, Ilias; US
ILLEI, Gabor; US
Agent:
CONNOLLY, Jodi, L.; Klarquist Sparkman, LLP One World Trade Center, Suite 1600 121 Sw Salmon Street Portland, OR 97204, US
Priority Data:
61/165,14231.03.2009US
Title (EN) DIFFERENTIALLY EXPRESSED MICRORNAS AS BIOMARKERS FOR THE DIAGNOSIS AND TREATMENT OF SJÖGREN'S SYNDROME
(FR) MICRO-ARN D'EXPRESSION DIFFÉRENTIELLE UTILISÉS COMME BIOMARQUEURS DU DIAGNOSTIC DU SYNDROME DE SJÖGREN ET TRAITEMENT ASSOCIÉ
Abstract:
(EN) The identification of differentially expressed microRNAs in patients with Sjögren's syndrome is disclosed herein. Provided is a method of diagnosing a subject as having Sjögren's syndrome by measuring the level of at least one differentially expressed miR gene product identified herein. An alteration in the level of the at least one miR gene product in the biological sample of the subject relative to a control indicates the subject has Sjögren's syndrome. Also provided is a method of treating a patient with Sjögren' s syndrome by administering to the patient a therapeutically effective amount of an agent that inhibits expression of a miR gene product that is up-regulated in the patient with Sjögren's syndrome relative to a control, or by administering to the patient a therapeutically effective amount of an isolated miR gene product that is down-regulated in the patient with Sjögren's syndrome relative to a control A method of restoring salivary flow in a patient with Sjögren' s syndrome is also provided.
(FR) Cette invention concerne l'identification de micro-ARN d'expression différentielle chez les patients atteints du syndrome de Sjögren. L'invention concerne une méthode de diagnostic d'un sujet atteint du syndrome de Sjögren en mesurant le taux d'au moins un produit génétique micro-ARN d'expression différentielle identifié dans l'invention. Une modification du taux dudit produit génétique du micro-ARN dans l'échantillon biologique prélevé chez le sujet par rapport à un témoin est indicatrice du syndrome de Sjögren chez le sujet. L'invention concerne également une méthode de traitement d'un patient atteint du syndrome de Sjögren en administrant audit patient une quantité thérapeutiquement efficace d'un agent qui inhibe l'expression d'un produit génétique de micro-ARN régulé à la hausse chez le patient par rapport à un témoin, ou en administrant audit patient une quantité thérapeutiquement efficace d'un produit génétique micro-ARN isolé qui est régulé à la baisse chez le patient atteint du syndrome de Sjögren par rapport à un témoin. L'invention concerne également une méthode permettant de restaurer le flux salivaire chez le patient atteint du syndrome de Sjögren.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)