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1. (WO2010117817) METHODS FOR GENERATING TARGET SPECIFIC PROBES FOR SOLUTION BASED CAPTURE

Pub. No.:    WO/2010/117817    International Application No.:    PCT/US2010/029276
Publication Date: Fri Oct 15 01:59:59 CEST 2010 International Filing Date: Wed Mar 31 01:59:59 CEST 2010
IPC: C12Q 1/68
C12N 15/11
Applicants: LIFE TECHNOLOGIES CORPORATION
RAYMOND, Christopher
Inventors: RAYMOND, Christopher
Title: METHODS FOR GENERATING TARGET SPECIFIC PROBES FOR SOLUTION BASED CAPTURE
Abstract:
Provided herein are compositions and kits for single-stranded nucleic acid probes, and methods for making the single-stranded nucleic acid probes, where the single-stranded nucleic acid probes comprise a probe region having a predetermined sequence which is flanked by a 5' region having a first restriction enzyme recognition sequence and flanked by a 3' region having a second restriction enzyme recognition sequence, and a region which hybridizes to a capture nucleic acid molecule. The single-stranded nucleic acid probes are useful for solution-based capture methods.