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1. (WO2010117800) SHH REGULATION AND METHODS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/117800    International Application No.:    PCT/US2010/029229
Publication Date: 14.10.2010 International Filing Date: 30.03.2010
IPC:
A61K 38/00 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Memorial Library 535 West 116th Street New York, NY 10027 (US) (For All Designated States Except US).
KOTTMANN, Andreas, Hugo [DE/US]; (US) (For US Only)
Inventors: KOTTMANN, Andreas, Hugo; (US)
Agent: LOVE, Jane, M.; Wilmer Cutler Pickering Hale And Dorr LLP 399 Park Avenue New York, NY 10022 (US)
Priority Data:
61/164,736 30.03.2009 US
Title (EN) SHH REGULATION AND METHODS THEREOF
(FR) RÉGULATION SHH ET MÉTHODES ASSOCIÉES
Abstract: front page image
(EN)The invention provides for methods of upregulating endogenous GDNF by inhibiting Shh signaling. The invention further provides a method for increasing the production of cholinergic neurons and dopamine neurons by subventricular zone (SVZ) neurogenesis in a subject. The invention further provides methods for treating a neurodegenerative disorder in a subject.
(FR)Cette invention concerne des méthodes de régulation positive du facteur endogène GDNF en inhibant le signal Shh. L'invention concerne par ailleurs une méthode d'augmentation de la production de neurones cholinergiques et de neurones de la dopamine par neurogenèse de la zone sous-ventriculaire (SVZ) chez un sujet. L'invention concerne également des méthodes de traitement des affections neurodégénératives chez un sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)