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Machine translation
1. (WO2010117438) COMPOUNDS THAT SUPPRESS CANCER CELLS AND EXHIBIT ANTITUMOR ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/117438    International Application No.:    PCT/US2010/001021
Publication Date: 14.10.2010 International Filing Date: 05.04.2010
IPC:
A61K 31/63 (2006.01), A61K 31/13 (2006.01), A61K 31/025 (2006.01)
Applicants: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. [US/US]; 12201 Research Pkwy. Suite 501 Orlando, FL 32826-3246 (US) (For All Designated States Except US).
UNIVERSITY OF TORONTO MISSISSAUGA [CA/CA]; 3359 Mississauga Road North Mississauga, ON LFL 1C6 (CA) (For All Designated States Except US).
TURKSON, James [CA/US]; (US) (For US Only).
GUNNING, Patrick [GB/CA]; (CA) (For US Only)
Inventors: TURKSON, James; (US).
GUNNING, Patrick; (CA)
Agent: ESTEVEZ, Enrique, G.; ALLEN, DYER, DOPPELT, MILBRATH & GILCHRIST, P.A. 255 South Orange Avenue, Ste. 1401 Orlando, FL 32810 (US)
Priority Data:
61/166,865 06.04.2009 US
61/246,695 29.09.2009 US
Title (EN) COMPOUNDS THAT SUPPRESS CANCER CELLS AND EXHIBIT ANTITUMOR ACTIVITY
(FR) COMPOSÉS QUI SUPPRIMENT LES CELLULES CANCÉREUSES ET PRÉSENTENT UNE ACTIVITÉ ANTITUMORALE
Abstract: front page image
(EN)The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs, Stat3 phosphorylation and nuclear translocation, Stat3 transcriptional function, and consequently induced Stat3-specific antitumor cell effects in vitro and antitumor response in vivo.
(FR)La présente invention concerne des composés S3I-201.1066 (Formule 1) et S3I-201.2096 (Formule 2) en tant qu'agents de liaison Stat3 sélectifs qui bloquent l'association de Stat3 avec les motifs pTyr du récepteur cognat, la phosphorylation de Stat3 et la translocation nucléaire, la fonction transcriptionnelle de Stat3, et par conséquent induisent des effets cellulaires antitumoraux spécifiques à Stat3 in vitro et une réponse antitumorale in vivo.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)