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1. (WO2010117419) METHOD OF DETERMINING BODY EXIT OF AN INGESTED CAPSULE

Pub. No.:    WO/2010/117419    International Application No.:    PCT/US2010/000941
Publication Date: Fri Oct 15 01:59:59 CEST 2010 International Filing Date: Wed Mar 31 01:59:59 CEST 2010
IPC: A61B 5/02
A61B 5/0215
A61K 9/48
Applicants: THE SMARTPILL CORPORATION
SEMLER, John, R.
SELOVER, Kathleen
ROHDE, Bermina, L.
Inventors: SEMLER, John, R.
SELOVER, Kathleen
ROHDE, Bermina, L.
Title: METHOD OF DETERMINING BODY EXIT OF AN INGESTED CAPSULE
Abstract:
A method of determining body exit of an ingestible capsule comprising the steps of providing (40) an ingestible capsule (20) having a pressure sensor (23), having (41) a subject ingest the capsule, recording (42a) measurements from the pressure sensor as the capsule passes through at least an end portion of a gastrointestinal tract of the subject, transmitting (44) the measurements to a processor (31) outside of the gastrointestinal tract of the subject, identifying (47) an increasing pressure sequence (65) in the measurements between a selected start time (62) and a transmission end time (63), comparing (48) the sequence to a reference (66), and using the comparison to make a determination (52) regarding the capsule exiting the gastrointestinal tract of the subject. The increasing pressure sequence may be the longest increasing pressure sequence in the measurements. The reference may be a logarithmic regression of the measurements. The ingestible capsule may further comprise a temperature sensor (22) and the method may further comprising the steps of recording (42b) measurements from the temperature sensor as the capsule passes through the end portion of the gastrointestinal tract of the subject, transmitting (43) the measurements to the processor, analyzing (46) the temperature measurements for a substantial drop (68) in the temperature measurements, and using the analysis of the temperature measurements to make the determination regarding the capsule exiting the gastrointestinal tract of the subject.