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1. (WO2010116899) PHOSPHORYLATION-INHIBITING AGENT OR DEPHOSPHORYLATING AGENT FOR PTEN
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/116899 International Application No.: PCT/JP2010/055378
Publication Date: 14.10.2010 International Filing Date: 26.03.2010
Chapter 2 Demand Filed: 06.10.2010
IPC:
C12N 9/18 (2006.01) ,A61K 31/7088 (2006.01) ,A61K 38/00 (2006.01) ,A61K 39/395 (2006.01) ,A61K 45/00 (2006.01) ,A61K 48/00 (2006.01) ,A61P 3/10 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/02 (2006.01) ,A61P 43/00 (2006.01) ,C12N 15/09 (2006.01) ,G01N 33/15 (2006.01) ,G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
18
Carboxylic ester hydrolases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15
Medicinal preparations
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
森下 和広 MORISHITA,Kazuhiro [JP/JP]; JP (UsOnly)
中畑 新吾 NAKAHATA,Shingo [JP/JP]; JP (UsOnly)
▲濱▼▲崎▼ 誠 HAMASAKI,Makoto [JP/JP]; JP (UsOnly)
国立大学法人宮崎大学 UNIVERSITY OF MIYAZAKI [JP/JP]; 宮崎県宮崎市学園木花台西1丁目1番地 1-1, Gakuen Kibana-dai Nishi, Miyazaki-shi, Miyazaki 8892192, JP (AllExceptUS)
財団法人宮崎県産業支援財団 Miyazaki Prefectural Industrial Support Foundation [JP/JP]; 宮崎県宮崎市佐土原町東上那珂16500‐2 16500-2, Higashi-Kaminaka Sadowara-cho, Miyazaki-shi, Miyazaki 8800303, JP (AllExceptUS)
Inventors:
森下 和広 MORISHITA,Kazuhiro; JP
中畑 新吾 NAKAHATA,Shingo; JP
▲濱▼▲崎▼ 誠 HAMASAKI,Makoto; JP
Agent:
特許業務法人 ユニアス国際特許事務所 UNIUS PATENT ATTORNEYS OFFICE; 大阪府大阪市淀川区西中島5丁目13-9 新大阪MTビル1号館 SHIN-OSAKA MT Bldg. 1, 13-9, Nishinakajima 5-chome, Yodogawa-ku, Osaka-shi, Osaka 5320011, JP
Priority Data:
2009-09514709.04.2009JP
Title (EN) PHOSPHORYLATION-INHIBITING AGENT OR DEPHOSPHORYLATING AGENT FOR PTEN
(FR) AGENT INHIBITEUR DE PHOSPHORYLATION OU AGENT DÉPHOSPHORYLISANT POUR PTEN
(JA) PTEN のリン酸化抑制剤又は脱リン酸化剤
Abstract:
(EN) Provided is a preventive, progression inhibitor or remedy for a disease one of the causes of which is the activation of the P13K/AKT signaling pathway or vice versa. A phosphorylation-inhibiting and/or dephosphorylating agent, which has an effect of inhibiting the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 and/or an effect of dephosphorylating the same, is prepared. Alternatively, a phosphorylation-inhibiting or dephosphorylating agent for PTEN is screened by a method comprising a step for confirming an ability of a test substance to inhibit the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 or a dephosphorylation ability thereof. Then, a substance having an effect opposite to the inhibition of PTEN phosphorylation or dephosphorylation thereof, which is presented by an antibody against the phosphorylation-inhibiting or dephosphorylating agent for PTEN obtained above, is obtained.
(FR) L'invention porte sur un inhibiteur de progression préventif ou un remède pour une maladie dont une des causes est l'activation de la voie de signalisation P13K/AKT ou vice versa. Il est préparé un agent inhibant la phosphorylation et/ou un agent désphosphorylant, qui a un effet d'inhibition de la phosphorylation au moins sur un des sites de phosphorylation de la protéine PTEN choisi dans le groupe constitué par T382, T383 ou S380 et/ou un effet de déphosphorylation de celui-ci. En variante, un agent inhibant la phosphorylation ou un agent déphosphorylant pour PTEN est criblé par un procédé comprenant une étape destinée à confirmer l'aptitude d'une substance test à inhiber la phosphorylation d'au moins un des sites de phosphorylation de la protéine PTEN choisi dans le groupe constitué par T382, T383 et S380 ou une capacité de déphosphorylation de celui-ci. Ensuite, on obtient une substance ayant un effet opposé à l'inhibition de la phosphorylation de PTEN ou de la déphosphorylation de celle-ci, laquelle est présentée par un anticorps dirigé contre l'agent inhibant la phosphorylation ou l'agent de déphosphorylation de PTEN obtenu ci-dessus.
(JA) PI3K/AKT情報伝達系の活性化あるいはその逆作用を病因のひとつとする疾病の予防薬、進展抑制薬、又は治療薬を提供する。PTENタンパク質のリン酸化部位T382、T383、及びS380からなる群より選択される少なくともひとつの部位のリン酸化を阻害する作用および/または脱リン酸化する作用を有するリン酸化阻害および/または脱リン酸化剤を調製する。あるいは、試験物質における、PTENタンパク質のリン酸化部位T382、T383、及びS380からなる群より選択される少なくとも1つの部位のリン酸化阻害能力または脱リン酸化能力を確認する工程を含む、PTENのリン酸化阻害または脱リン酸化剤のスクリーニングを行う。さらに、得られたPTENのリン酸化阻害または脱リン酸化剤に対する抗体に例示される、PTENのリン酸化阻害または脱リン酸化と逆の作用を有する物質を得る。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)