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1. (WO2010116302) IMIDAZ0[1,2-A] PYRIDINE-6-CARBOXAMIDE DERIVATIVES, THEIR USE FOR THE TREATMENT OF COLON CANCER AND THEIR METHOD OF MANUFACTURE

Pub. No.:    WO/2010/116302    International Application No.:    PCT/IB2010/051427
Publication Date: Fri Oct 15 01:59:59 CEST 2010 International Filing Date: Fri Apr 02 01:59:59 CEST 2010
IPC: C07D 471/04
A61K 31/437
A61P 35/00
Applicants: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
FARKAS (NEE NURIT), Esperance Dahan
DAVIDS, Hajierah
LANGLEY, Candice
DE KONING, Charles Bernard
Inventors: FARKAS (NEE NURIT), Esperance Dahan
DAVIDS, Hajierah
LANGLEY, Candice
DE KONING, Charles Bernard
Title: IMIDAZ0[1,2-A] PYRIDINE-6-CARBOXAMIDE DERIVATIVES, THEIR USE FOR THE TREATMENT OF COLON CANCER AND THEIR METHOD OF MANUFACTURE
Abstract:
This invention relates to the manufacture of novel chemical compounds which have biological activity, particularly to novel chemical compounds that are cytotoxic against colon cancer cells and colon cancer cell lines. The manufacturing of said chemical compounds displaying anti-cancer properties employs the use of multi-component chemical reactions. The object of this invention is to manufacture and isolate analogues of imidazo[1,2-a]pyridine, namely compounds of Formula 1, which are cytotoxic against colon cancer cells, while concomitantly being relatively inactive against white blood cells. Formula 1 wherein, R is bromo, methyl, phenyl, nitro, hydrogen or an amide functional group; R1 is benzyl, 2,6-dimethylphenyl or cyclohexyl; and R2 is methoxy, benzyloxy or hydroxy.