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1. (WO2010116258) NEURON GENERATION, REGENERATION AND PROTECTION

Pub. No.:    WO/2010/116258    International Application No.:    PCT/IB2010/000967
Publication Date: Fri Oct 15 01:59:59 CEST 2010 International Filing Date: Sat Apr 03 01:59:59 CEST 2010
IPC: C12N 15/47
C12N 15/86
C07K 14/145
A61K 38/17
A61K 48/00
Applicants: INSTITUT PASTEUR
THOMAS JEFFERSON UNIVERSITY
PREHAUD, Christophe
LAFON, Monique
SCHNELL, Matthias, Johannes
Inventors: PREHAUD, Christophe
LAFON, Monique
SCHNELL, Matthias, Johannes
Title: NEURON GENERATION, REGENERATION AND PROTECTION
Abstract:
The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth promoting effect. The invention further demonstrates that this neurite outgrowth promoting effect is due to the cytoplasmic tail of said non-apoptotic rabies virus G proteins, more particularly to their PDZ-BS, which shows a single-point mutation compared to the one of apoptotic rabies virus G proteins. The invention provides means for inducing and/or stimulating neurite outgrowth, which are useful in inducing neuron differentiation, for example for the treatment of a neoplasm of the nervous system, as well as in regenerating impaired neurons, for example for the treatment of a neurodegenerative disease, disorder or condition or in the treatment of a microbial infection, or in protecting neurons from neurotoxic agents or oxidative stress.