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1. (WO2010116132) BISPHOSPHONATE COMPOUNDS FOR CHELATING RADIONUCLIDES

Pub. No.:    WO/2010/116132    International Application No.:    PCT/GB2010/000692
Publication Date: Fri Oct 15 01:59:59 CEST 2010 International Filing Date: Thu Apr 08 01:59:59 CEST 2010
IPC: C07F 9/38
C07F 9/02
A61K 33/42
A61K 35/04
Applicants: KING'S COLLEGE LONDON
BLOWER, Philip, John
TORRES MARTIN DE ROSALES, Rafael
Inventors: BLOWER, Philip, John
TORRES MARTIN DE ROSALES, Rafael
Title: BISPHOSPHONATE COMPOUNDS FOR CHELATING RADIONUCLIDES
Abstract:
Bisphosphonate compounds for chelating radionuclides are described which have separate bisphosphonate and metal chelating groups joined by a linker, so that the bisphosphonate groups are available to complex to hydroxyapatite in bone, while the metal chelating group binds to the radionuclide. This avoids problems in the prior art, where the bisphosphonate groups are used for both binding functions which compromises the bone-seeking activity of the bisphosphonate groups when they are used to chelate the radionuclide.