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1. (WO2010116132) BISPHOSPHONATE COMPOUNDS FOR CHELATING RADIONUCLIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/116132    International Application No.:    PCT/GB2010/000692
Publication Date: 14.10.2010 International Filing Date: 07.04.2010
IPC:
C07F 9/38 (2006.01), C07F 9/02 (2006.01), A61K 33/42 (2006.01), A61K 35/04 (2006.01)
Applicants: KING'S COLLEGE LONDON [GB/GB]; The Strand London WC2R 2LS (GB) (For All Designated States Except US).
BLOWER, Philip, John [GB/GB]; (GB) (For US Only).
TORRES MARTIN DE ROSALES, Rafael [ES/GB]; (GB) (For US Only)
Inventors: BLOWER, Philip, John; (GB).
TORRES MARTIN DE ROSALES, Rafael; (GB)
Agent: KIDDLE, Simon, J.; Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS (GB)
Priority Data:
0906068.2 07.04.2009 GB
Title (EN) BISPHOSPHONATE COMPOUNDS FOR CHELATING RADIONUCLIDES
(FR) COMPOSÉS DE BISPHOSPHONATE DESTINÉS À CHÉLATER DES RADIONUCLÉIDES
Abstract: front page image
(EN)Bisphosphonate compounds for chelating radionuclides are described which have separate bisphosphonate and metal chelating groups joined by a linker, so that the bisphosphonate groups are available to complex to hydroxyapatite in bone, while the metal chelating group binds to the radionuclide. This avoids problems in the prior art, where the bisphosphonate groups are used for both binding functions which compromises the bone-seeking activity of the bisphosphonate groups when they are used to chelate the radionuclide.
(FR)La présente invention concerne des composés de bisphosphonate destinés à chélater des radionucléides, qui comprennent des bisphosphonate et des groupes chélatant les métaux reliés par un lieur, de sorte que les groupes bisphosphonate soient disponibles pour complexer l'hydroxyapatite dans les os, tandis que les groupes chélatant les métaux se lient au radionucléide. Ceci permet d'éviter les problèmes observés dans l'art antérieur, où les groupes bisphosphonate sont utilisés pour les deux fonctions de liaison, ce qui compromet l'activité ostéotrope des groupes bisphosphonate lorsqu'ils sont utilisés pour chélater les radionucléides.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)