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1. (WO2010116096) METHOD FOR PURIFYING THE RABIES VIRUS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/116096 International Application No.: PCT/FR2010/050679
Publication Date: 14.10.2010 International Filing Date: 08.04.2010
IPC:
C12N 7/02 (2006.01) ,A61K 39/205 (2006.01)
Applicants: SANOFI PASTEUR[FR/FR]; 2 avenue Pont Pasteur F-69367 Lyon cedex 07, FR
Inventors: FABRE, Virginie; FR
ROCCA, Céline; FR
RIFFARD, Pierre; FR
CALVOSA, Eric; FR
Priority Data:
095231008.04.2009FR
61/231,39405.08.2009US
Title (EN) METHOD FOR PURIFYING THE RABIES VIRUS
(FR) PROCEDE DE PURIFICATION DU VIRUS RABIQUE
Abstract:
(EN) The subject matter of the invention is a method for purifying the rabies virus, comprising a single step of ion exchange chromatography, said step being a cation exchange chromatography according to which: a) the supernatant of a culture of cells infected with this virus is brought into contact with a cation exchange chromatography substrate comprising a matrix of polymethacrylate onto which sulphoisobutyl groups have been grafted such that the rabies virus binds to this substrate, and b) the virus is eluted from the substrate thereof.
(FR) L'invention a pour objet un procédé de purification du virus rabique comprenant une seule étape de chromatographie par échange d'ions, la dite étape étant une chromatographie par échange de cations selon laquelle : a) on met en contact le surnageant d'une culture de cellules infectées par ce virus avec un support de chromatographie échangeur de cations comprenant une matrice de polyméthacrylate sur laquelle ont été greffés des groupements sulfoisobutyl de telle sorte que le virus rabique se fixe sur ce support, et b) on élue le virus de son support.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)